Lupus Erythematosus and Chronic Granulomatous Disease: Report of Four Iranian Patients with AR-CGD and One XL-CGD.

Lupus Erythematosus and Chronic Granulomatous Disease: Report of Four Iranian Patients with AR-CGD and One XL-CGD.
Iran J Allergy Asthma Immunol. 2019 Aug 17;18(4):452-458
Authors: Maddah M, Fazlollahi MR, Shiari R, Shahram F, Mamishi S, Babaie D, Monajemzadeh M, Sotudeh S, Hamidieh AA, Badalzadeh M, Tajik S, Sedighipour L, Pourpak Z
Abstract
Chronic granulomatous disease (CGD) is a rare genetic disorder of neutrophil activity, resulting in increased rate of recurrent infections with catalase-positive bacteria and fungi, as well as various autoimmune diseases such as sarcoidosis, rheumatoid arthritis, and discoid and/or systemic lupus erythematosus. Few reports have reported lupus erythematosus (LE) in patients with X-linked CGD (XL-CGD) and carriers, and very few in autosomal recessive CGD (AR-CGD). Here, we present 5 patients with CGD developing LE at different ages to emphasize on the importance of appropriate follow-up and treatment in patients with CGD with clinical signs and symptoms of autoimmune diseases and even in those with negative serologic results.
PMID: 31522454 [PubMed - in process]

Source: Iranian Journal of Allergy, Asthma and Immunology - August 16, 2019 Category: Allergy & Immunology Authors: Maddah M, Fazlollahi MR, Shiari R, Shahram F, Mamishi S, Babaie D, Monajemzadeh M, Sotudeh S, Hamidieh AA, Badalzadeh M, Tajik S, Sedighipour L, Pourpak Z Tags: Iran J Allergy Asthma Immunol Source Type: research