Metformin treatment in young children with fragile X syndrome

ConclusionThese results support the need for a controlled trial of metformin in children with FXS under 7  years old whose brains are in a critical developmental window and thus may experience a greater degree of clinical benefit from metformin.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Authors: Campos-Borges HC, Sanz-González SM, Zanón-Moreno V, Millán Salvador JM, Pinazo-Duran MD PMID: 31629562 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
In this study, we assessed effects of LPZ on adipocyte differentiation and function by using 3T3-L1 preadipocytes and HFD-induced obesity mice as an in vitro and in vivo model, respectively.Main methodsOil red O staining and intracellular triacylglycerol content were used to determine lipid accumulation. Glucose uptake was performed to measure mature adipocyte function. Expression of adipocyte genes was determined by qRT-PCR and immunoblotting.Key findingsLPZ has dual effects on differentiation of 3T3-L1 cells. At low concentrations, LPZ enhanced adipocyte differentiation via induction of PPARγ and C/EBPα, two ...
Source: Life Sciences - Category: Biology Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
CONCLUSIONS The subgroups with increased risk of developing multiple unhealthy behaviors and the most prevalent behaviors were identified. These findings are expected to contribute to the better targeting of health promotion and preventive care. It is worth noting that, for the adoption of healthy lifestyle habits, macro-social and inter-sectoral policies are more effective.RESUMO OBJETIVO Estimar a coocorr ência dos principais fatores de risco para doenças crônicas não transmissíveis em adultos (18 a 59 anos) e idosos ( ≥ 60 anos) residentes nas capitais dos estados brasileiros e Distri...
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
CONCLUSIONS Our findings showed that about 20% of the youths had at least one mental disorder. However, this prevalence is underestimated since other relevant mental disorders were not assessed. Mental disorders were associated with higher suicide risk, especially the comorbidity between them.
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy homeostasis, drug addiction, and cognitive processes. These effects are mediated by two G protein-coupled receptor (GPCR) subtypes named OX1R and OX2R. In accordance with the synergic and dynamic relationship between the nervous and immune systems, orexins also have neuroprotective and immuno-regulatory (i.e., anti-inflammatory) properties. The present review gathers recen...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionsLinagliptin showed cardiovascular and renal safety in Asian patients with T2DM and established CVD with albuminuria and/or kidney disease.
Source: Diabetology International - Category: Endocrinology Source Type: research
Two UCLA professors, Dr. Denise Aberle and Dr. Carol Mangione, have been elected to the National Academy of Medicine, one of the highest honors in health and medicine.Aberle is a professor of radiology and bioengineering, and vice chair for research in the department of radiological sciences at theDavid Geffen School of Medicine at UCLA. Mangione is the Barbara A. Levey&Gerald S. Levey  Professor of Medicine and Public Health and chief of the division of general internal medicine and health services research. They were among 100 new members announced Oct. 21 during the academy’s annual meeting in Washington,...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Conversations and healthy debate about issues facing our industry and the health care system are critical to addressing some of today ’s challenges and opportunities. The Catalyst welcomes guest contributors, including patients, stakeholders, innovators and others, to share their perspectives and point of view. Views represented here may not be those of PhRMA, though they are no less key to a healthy dialogue on issues in health care today.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: diabetes Out of Pocket Costs Voters for Cures Source Type: news
In conclusion, CWE seem to benefit from interventions and behavior modification techniques first developed for children with ADHD.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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