Clinical Utility of a Semiquantitative Method Using Lumbar Radiography as a Screening Tool for Osteoporosis in Elderly Subjects.

Clinical Utility of a Semiquantitative Method Using Lumbar Radiography as a Screening Tool for Osteoporosis in Elderly Subjects. Med Sci Monit. 2019 Sep 14;25:6928-6934 Authors: Kunitoki K, Mutoh T, Tatewaki Y, Takano Y, Yamamoto S, Shimomura H, Nakagawa M, Arai H, Taki Y Abstract BACKGROUND Osteoporosis is a major global public health problem in the current aging era. Osteoporosis is often diagnosed only after patients have a fracture that causes a severe decline in ability to perform activities of daily life. Although the current criterion standard for diagnosing osteoporosis is dual-energy X-ray absorptiometry (DXA), this modality remains less prevalent among general practitioners in geriatric medicine. The aim of this study was to determine the diagnostic utility of visual inspection of lumbar radiography in detecting bone mineral density (BMD) decline. MATERIAL AND METHODS We retrospectively reviewed medical data of 78 patients who underwent both lateral lumbar radiography and DXA. Board-certified radiologists determined the clinical grade of each patient's condition according to the semiquantitative (SQ) method of lumbar fracture assessment. We compared the grades and young adult means of BMD in the lumbar spine and hips as measured using DXA. RESULTS BMD of the femoral neck was significantly lower in patients with severe osteoporosis (grades 2 and 3 as classified using the SQ method) than in those with mild osteoporosis (grades 0 and 1; P
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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AbstractObjectivesTo develop and evaluate a method for areal bone mineral density (aBMD) measurement based on dual-layer spectral CT scout scans.MethodsA post-processing algorithm using a pair of 2D virtual mono-energetic scout images (VMSIs) was established in order to semi-automatically compute the aBMD at the spine similarly to DXA, using manual soft tissue segmentation, semi-automatic segmentation for the vertebrae, and automatic segmentation for the background. The method was assessed based on repetitive measurements of the standardized European Spine Phantom (ESP) using the standard scout scan tube current (30  ...
Source: European Radiology - Category: Radiology Source Type: research
Conclusions: Low bone mass and deteriorated TBS were noted in approximately two-thirds of T2DM women and was also associated with vertebral fracture. In addition to aging, poor glycemic control may play an important role in bone remodeling, which may be associated with changes in bone strength in T2DM women. Bone strength together with clinical risk factors has the strongest association with fracture, and may potentially be useful to identify women with T2DM at risk.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
ConclusionsThe trabecular parts of the alveolar and basal bones and the MCW were not significantly altered by BP treatment in patients with osteoporosis over 4.3 –5 years, as detected by digital periapical and panoramic radiography. The low dosages of bisphosphonates used in the treatment of osteoporosis may explain this lack of change in MCW. Dental radiographs should not be considered as a method to monitor BP-induced jaw bone alterations among osteopor otic patients.
Source: Oral Radiology - Category: Radiology Source Type: research
ConclusionSignificant associations between LRP5 SNPs (p.A1330V, p.N740N, and p.V667M) and the severity of radiographic damage reinforce the evidence of bone destruction heritability in RA.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Statement of the Problem: Reduced bone mineral density (BMD) generally affects postmenopausal women and it is classified into moderate (osteopenia) and significant osteoporosis. Based on digital panoramic radiographs (DPRs), several quantitative and qualitative assessment methods have been proposed for the diagnosis and evaluation of bone changes and as a predictor of BMD.Purpose: The aim of this study was to compare mandibular cortical width (MCW) and mandibular cortical index (MCI) derived from DPRs in evaluating the BMD in osteopenic and osteoporotic post-menopausal women.Materials and Method: In this cross-sectional st...
Source: Journal of Dentistry, Shiraz University of Medical Sciences - Category: Dentistry Source Type: research
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 55-year-old woman is evaluated for a new-patient visit. Medical history is significant for an eating disorder. Although she has maintained a normal weight for the past 20 years, she notes that prior to that time her weight would fluctuate in a range correlating with BMIs of 17 to 19. She has otherwise been healthy and currently feels well. She is postmenopausal and a never-smoker. Family history is significant for postmenopausal osteoporosis in her mother. Her medications are over-the-counter calcium a...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Endocrinology Source Type: blogs
ConclusionSignificant associations between LRP5 SNPs (p.A1330V, p.N740N, and p.V667M) and the severity of radiographic damage reinforce the evidence of bone destruction heritability in RA.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Abstract The purpose of this work was to present a new approach that allows the influence of cortical bone on noninvasive measurement of broadband ultrasound attenuation (BUA) to be corrected. The method, implemented here at 1 MHz makes use of backscattered signal and once refined and clinically confirmed, it would offer an alternative to ionizing radiation based methods, such as DEXA (Dual-energy X-ray absorptiometry), quantitative computed tomography (QCT), radiographic absorptiometry (RA) or single X-ray absorptiometry (SXA), which are clinically approved for assessment of progress of osteoporosis. In additio...
Source: Ultrasonics - Category: Physics Authors: Tags: Ultrasonics Source Type: research
Abstract Context: Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) was able to predict fracture risk. High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding of fracture susceptibility. Objective: To ascertain whether vBMD, microarchitecture and estimated bone strength derived from HR-pQCT can discriminate vertebral fractures in glucocorticoid-induced osteoporosis (GIOP) patients independent of aBMD. Design: A cross-sectional ca...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
ConclusionsIn men and women, early decreased renal function (eGFR
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
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