FujiLAM Prospective Evaluation Trial

Condition:   Diagnosis of Tuberculosis in People Living With HIV Intervention:   Device: Fujifilm SILVAMP TB LAM Sponsors:   Foundation for Innovative New Diagnostics, Switzerland;   Centre for Infectious Disease Research in Zambia;   Infectious Diseases Institute, Uganda;   Malawi-Liverpool-Wellcome Trust Clinical Research Programme;   Swiss TPH, Switzerland;   Ifakara Health Institute, Tanzania;   University of Cape Town;   Viet Tiep Hospital, Vietnam;   National TB Control Program based on National Lung Hospital Vietnam;   Fujifilm Corporation, Japan;   Omega Diagnostics, United Kingdom Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conclusions: A six-month course of isoniazid proved to be safe and effective in the treatment of LTBI, which is essential to reducing the risk of developing active tuberculosis.RESUMO Objetivo: Descrever a incid ência de tuberculose ativa e a ocorrência de eventos adversos do tratamento com isoniazida em pacientes diagnosticados com tuberculose latente (TBL), portadores de doenças inflamatórias crônicas e tratados com agentes imunobiológicos em uma área endêmica no Brasil. Métodos: O diagnóstico de TBL foi feito com base em anamnese, exame clínico, ra...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
To describe the surgical techniques in a case of female genital tuberculosis (TB) with superimposed tubo-ovarian abscess (TOA) in a developed country.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 1: Laparoscopy (10:00 AM — 10:10 AM) 10:00 AM: STATION P Source Type: research
[The Herald] Zimbabwe has paid US$300 000 to the Global Fund to fight Aids, Tuberculosis and Malaria in addition to another US$200 000 which was paid a fortnight ago for its 2017-2019 commitment.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[Cameroon Tribune] The event which was yesterday, October 10, 2019 presided over by the French President, Emmanuel Macron ended with donors attaining the 14 billion dollar target.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
ACS Chemical BiologyDOI: 10.1021/acschembio.8b00849
Source: ACS Chemical Biology - Category: Chemistry Authors: Source Type: research
S Turkucar, B Makay, H Tatari, E UnsalJournal of Postgraduate Medicine 2019 65(4):233-236 Pigmented villonodular synovitis (PVNS) is a rare benign disorder of a joint which affects its synovium, tendon sheaths and bursas. While most cases of PVNS are adult patients aged between 20-50 years, few afflicted children have also been reported. Clinical signs of PVNS are insidious and non-specific. Pain, swelling and stiffness are the major symptoms. Magnetic Resonance Imaging (MRI) is the best radiological method for diagnosis of PVNS, as the initial X-ray is normal in early phase of disease in most cases. Therefore, diagnosis ...
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
In this study, we further determined that Rv1768 was highly conserved among virulent M.tb strains and mainly distributed as a secreted protein. Exposure to recombinant purified Rv1768 (rRv1768) induced apoptosis of bone marrow derived macrophages (BMDMs) but showed no dose-dependent manner. Regarding macrophage activation, significant higher levels of iNOS and pro-inflammatory cytokines (like IL-6 and TNF-α) were detected in rRv1768-challenged BMDMs, whereas arginase 1 (Arg1) expression was markedly decreased. Meanwhile, MHC-II expression and antigen presentation activity of BMDMs were also enhanced by rRv1768 stimul...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: Available online 12 October 2019Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): Q. Xu, M. Lv, Y. Xia, Y. Zhao, W. Zhang, Y. ChenAbstractA 42-year-old woman presented with a ten-day history of dysphagia, slight chest pain and occasional vomiting. With the performance of thoracic and abdominal enhanced computed tomography (CT) and upper gastrointestinal contrast, once esophageal cancer was suspected. Significant activity mass in esophagus and mediastinal lymph nodes could be found on the imaging of 18F-FDG PET/CT, which also supported malignancy. However, T...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Myeloid HIF-1α regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection. Immunology. 2019 Oct 13;: Authors: Resende M, Ferreira CM, Barbosa AM, Cardoso MS, Sousa J, Saraiva M, Castro AG, Appelberg R, Torrado E Abstract The transcription factor hypoxia inducible factor-1 alpha (HIF-1α) is as key regulator of the response and function of myeloid cells in hypoxic and inflammatory microenvironments. To define the role of HIF-1α in tuberculosis, the progression of aerosol Mycobacterium tuberculosis infection was analyzed in mice deficient in HIF-1&alp...
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
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