Evaluation of thyroid nodules classified as bethesda category III on cytology and their malignancy rate: An institutional experience

Conclusion: Diagnostically, we almost meet the international standards of designating cases with AUS/FLUS (Bethesda category III) and approximate the risk of malignancy. However, the clinical management's guidelines should be followed to decrease the risk of unnecessary surgeries and their complications. There is a statistically significant correlation between the age and gender with the final histopathology report, respectively.
Source: CytoJournal - Category: Pathology Authors: Source Type: research

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In conclusion, despite the low prevalence of IET and cervical EET, clinicians and radiologists should be aware of US characteristics of such lesions and of the necessity of confirmation of their benign character. Elastography is a useful tool to initially differentiate PTC and IET. However, due to the high risk of malignancy in thyroid lesions in children, similarity of US features of PTC and IET, and because of the possibility of malignancy in ET, only cytological evaluation provides definitive diagnosis and prevents, on one hand, unnecessary frequent diagnostic procedures and/or surgery and, on the other hand, missing ma...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract BACKGROUND: Medullary thyroid cancer (MTC) accounts for 5% of all thyroid cancers and occurs either sporadically or in a hereditary pattern. Routine calcitonin (CT) measurement is suggested for MTC screening in patients with nodular thyroid disease. Patient Findings A 45 years-old woman incidentally discovered, with neck ultrasound, the presence of thyroid micronodules. Fine-needle aspiration (FNA) on thyroid prevailing nodule did not demonstrate cellular atypia. During follow-up, FNA was repeated on the previously analyzed nodule suspicious for Hürthle cell nodule suspicious for follicular neoplasm ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
This study shows that the false-negative rate of thyroid FNA at our institution is not significantly above the rate suggested by the BSRTC. Interpretation errors were more likely to occur in follicular patterned neoplasms, while non-FVPTC was more frequently found in false negative cases due to inadequate sampling.
Source: Endocrine Pathology - Category: Pathology Source Type: research
CONCLUSIONS: The indeterminate FNA still remains a challenge for the surgeon because it is not yet possible to discriminate patients who really need surgery from those that can be followed in follow-up. The potential of molecular diagnostics for thyroid nodules with indeterminate cytology is promising, but many of these markers are too complex or expensive for routine clinical use or are still poorly standardized. KEY WORDS: Indeterminate FNA, Thyroid, Thyroid fine needle aspiration. PMID: 28632145 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
We present the case of a 46-year-old female with a large right nodular goiter and hypothyroidism and high titer of anti-thyroid peroxidase antibody (TPO). The thyroid ultrasound showed a large well-defined nodule (more than 6.8 cm) with hypoechogenicity and microcalcification. FNAC (Mayo Clinic technique) smears revealed HC arranged in flat sheets in 75% in the sample with moderate nuclear pleomorphism, abundant granular cytoplasm showing eosinophilia and well-defined cytoplasmic borders, a lightly eccentric enlarged nuclei; the colloid was reduced and lymphocytes were also described. The final histological examination rev...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Conclusion de Quervain's thyroiditis is an inflammatory condition of the thyroid that is rarely treated surgically. However when presentation is atypical and the FNAC is inconclusive or is suspicious for a malignancy, patients receive surgery putting them at a risk for morbidity. Good clinical assessment with combined use of ultrasound with FNAC especially read by an experienced cyto-pathologist has the potential to reduce unnecessary operative intervention.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Conclusion Although the coexistence of them are rare, thyroid malignancy should be put in the differential diagnosis of hyperthyroid goiter.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionThyroid aspirates with predominance of squamous cells cannot be classified in the current Bethesda categories. Even when interpreted as atypical or equivocal, the squamous cells present in our small case series were mostly benign. The only malignant case was easily identified cytologically because of its higher degree of differentiation. The most common pitfall for atypical squamous cells in these aspirates was squamous metaplasia in the setting of Hashimoto thyroiditis and degenerative changes. Diagn. Cytopathol. 2016. © 2016 Wiley Periodicals, Inc.
Source: Diagnostic Cytopathology - Category: Pathology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Patients with focal 68Ga-DOTATATE uptake should undergo further examination (FNA) due to potential risk of malignancy. Diffuse 68Ga-DOTATATE uptake was predominantly associated with active autoimmune thyroiditis or benign goitre. The focal lesions and diffuse pathology diseases were frequently seen in women. (Endokrynol Pol 2015; 66 (3): 231-236). PMID: 26136132 [PubMed - in process]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
Abstract: Papillary thyroid carcinoma (PTC) is a common diagnosis and makes up the vast majority of thyroid carcinomas. Papillary thyroid carcinoma is often diagnosed preoperatively by fine-needle aspiration of a thyroid nodule or abnormal-appearing lymph node. The diffuse sclerosing variant of PTC is a rare subtype and is disproportionately diagnosed in younger patients. The major pitfall on thyroid fine-needle aspiration is a diagnosis of lymphocytic thyroiditis (Hashimoto thyroiditis). This variant of PTC has characteristic histologic features including a lymphocytic infiltrate, foci of squamous metaplasia, abundant psa...
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research
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