Urticaria & angioedema: a rational approach to diagnosis and therapy.

Urticaria &angioedema: a rational approach to diagnosis and therapy. Skin Therapy Lett. 2013 Jan;18(1):4-9 Authors: Dreyfus DH Abstract Urticaria and angioedema are common allergic manifestations and some forms of this disorder may be increasing in both prevalence and severity due to changes in medications, environment and other unknown factors. This review focuses on a rational approach to differential diagnosis and therapy of the most common forms of urticaria and angioedema. PMID: 23474656 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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one Precision beekeeping or precision apiculture is an apiary management strategy based on the monitoring of individual bee colonies to minimize resource consumption and maximize the productivity of bees. Bees play a fundamental role in ensuring pollination; they can also be considered as indicators of the state of pollution and are used as bio monitors. Beekeeping needs continuous monitoring of the animals and can benefit from advanced intelligent ambiance technologies. The aim of this study was the design of a precision apiculture system (PAS) platform for monitoring and controlling the following environmental parame...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
The objectives of this study were to analyse a possible relationship between parasitism by Ascarididae (Toxocara canis andAnisakis simplex) and the clinical expression of urticaria and to identify possible parasitic molecular markers for improving the diagnosis of unknown urticaria aetiology. The prevalence ofToxocara andAnisakis infestations was evaluated by measuring the levels of specific IgG (sIgG) and IgE (sIgE) antibodies against crude extracts and isolated components from whole larvae ofAnisakis simplex (Ani s 1, Ani s 3 and Ani s 7) andToxocara canis (TES-120, TES-70, TES-32 and TES-26) using immunologic and molecu...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research
AbstractLevocetirizine is classified as a second ‐generation antihistamine. Levocetirizine is available for the treatment of allergic disorders such as allergic rhinitis and chronic idiopathic urticaria. This was a single‐center, single‐dose, open‐label, randomized, 2‐way crossover study in healthy Japanese male subjects consisting of 2 parts. Part 1 compared the bioavailability of levocetirizine oral disintegrating tablet (ODT) and levocetirizine immediate‐release tablet (IRT) taken with water in the fasted state in 24 subjects; all subjects completed this part of the trial. In part 2, the bioavailability of l...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
We report a case of chronic urticaria associated withE. nana in a 34-year-old Italian woman. The patient suffered from abdominal pain, diarrhoea and weight loss. The disease appeared after a trip to Vietnam. Laboratory examinations showed mild blood eosinophilia. Three coproparasitological examinations were positive for cysts ofE. nana. The patient was successfully treated with two courses of metronidazole (2 g/day for 10 days each). No antihistamines were used. Three coproparasitological examinations, carried out at the end of the therapy, were negative. Follow up (six months) was negative.E. nana can be responsible for v...
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
AbstractPurpose of reviewChronic spontaneous urticaria (CSU) is frequently associated with autoimmunity and is often exacerbated by several factors. These include stress, infections, colourings and preservatives in pre-packaged foods, as well as deficiency of vitamin D3 and iron. While chronic underlying infection and mental and emotional stress have been known to precede the onset of CSU, it is now clear that they can also aggravate the severity of the symptoms and perpetuate the condition. It is unclear how gastrointestinal dysbiosis affects CSU. Vitamin D3, however, can increase T regulatory function which can control a...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
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Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Tags: Aerius Allegra Antihistamines Atarax Benadryl cetirizine Clarinex Claritin Desloratadine diphenhydramine Fexofenadine Hydroxyzine levocetirizine Quzyttir Reactine Urticaria Vistaril Xyzal Zyrtec Source Type: research
Chronic spontaneous urticaria (CSU) is considered to be primarily a mast cell-driven disease. However, recent evidence suggests that eosinophils may also have an axial role in symptomology. Histological studies have demonstrated the presence of both eosinophils and eosinophil granules, indicative of activation, in CSU lesions. While many allergic and inflammatory conditions are associated with a peripheral blood eosinophilia, the converse appears to be the case in CSU, a peripheral blood eosinopenia being observed in many patients.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
A role for the adhesion G-protein coupled receptor ADGRE2 (EMR2) in mechanosensing was revealed by the finding of a missense substitution (p.C492Y) associated with familial vibratory urticaria (VU). In these patients, friction of the skin induces mast cell hyper-degranulation through p.C492Y-ADGRE2, causing localized hives, flushing and hypotension. We have now characterized the responses and intracellular signals elicited by mechanical activation in human mast cells expressing p.C492Y-ADGRE2 and attached to dermatan sulfate, a ligand for ADGRE2.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
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