Dermatitis herpetiformis.

This article will provide a comprehensive review of DH, including its epidemiology, clinical and pathological findings, diagnostic evaluation, and management. PMID: 23674144 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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Abstract Dermatitis herpetiformis (DH) is an autoimmune skin disease that causes itchy, blistering rash, typically on the elbows, knees and buttocks. DH and coeliac disease share the same genetic background, gluten-dependent enteropathy and antibody response against tissue transglutaminase. DH is currently considered a cutaneous manifestation of coeliac disease, and the prevailing hypothesis is that DH develops as a late manifestation of subclinical coeliac disease. The incidence of DH is decreasing contemporarily with the increasing incidence of coeliac disease. The IgA immune response in DH skin is directed agai...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Conditions:   Alopecia Areata;   Depressive Episode;   Recurrent Depressive Disorder;   Anxiety Disorders;   Atopic Dermatitis;   Allergic Rhinitis;   Asthma;   Crohn Disease;   Ulcerative Colitis;   Pernicious Anemia;   Type 1 Diabetes;   Hashimoto Thyroiditis;   Graves Disease;   Rheumatoid Arthritis;   Psoriatic Arthritis;   Ankylosing Spondylitis;   Systemic Lupus Erythematosus;   Polymyalgia Rheumatica;   Sjogren's Syndro...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Noori E, Kazemi B, Bandehpour M, Zali H, Khalesi B, Khalili S Abstract Coeliac disease (CD) is a chronic autoimmune disease that is characterized by malabsorption in sensitive individuals. CD is triggered by the ingestion of grains containing gluten. CD is concomitant with several other disorders, including dermatitis herpetiformis, selective IgA deficiency, thyroid disorders, diabetes mellitus, various connective tissue disorders, inflammatory bowel disease, and rheumatoid arthritis. The advent of high throughput technologies has provided a massive wealth of data which are processed in various omics scale...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
CONCLUSIONS: At adolescence, both Crohn's disease and ulcerative colitis are associated with multiple comorbidities, not limited to autoimmune disorders. PMID: 31801156 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Atopic dermatitis (AD) is an eczematous inflammatory skin disease being the most common skin disease in children. AD is associated with an increased risk for several atopic, somatic and psychiatric comorbidities. Recent epidemiological data suggests that AD patients are at risk for autoimmune diseases, but the risk of celiac disease (CD) in children and adolescents with AD has shown conflicting results. Dermatitis herpetiformis (DH) is a rare autoimmune bullous skin disease with worldwide highest prevalence in Finland.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Atopic dermatitis (AD) is associated with a wide range of comorbidities, particularly allergies, but its association with nonatopic autoimmune disease is less well defined. Recent genome-wide association studies have reported shared genetic loci between AD and autoimmune diseases. In the UK, most patients with these conditions are managed in primary care, meaning general practice (GP) databases provide a rich data source for studying AD. A retrospective cohort study was undertaken to examine the association between AD and the following autoimmune diseases (rheumatoid arthritis [RA], ulcerative colitis [UC], Crohn ’s ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Abstract: Dermatitis herpetiformis is a rare, chronic autoimmune disorder characterized by intense pruritic papules and vesicles, which can be associated with celiac disease and other autoimmune disorders. Its histologic characteristic is the accumulation of neutrophils within the papillary dermis with granular deposition of immunoglobulin A (IgA) observed under direct immunofluorescence. Herein, we report a 58-year-old woman who presented with a vesicular rash on the buttocks. The patient reported a recent history of genital herpes, Entamoeba histolytica colitis, recurrent hives, and eczema. A representative biopsy demo...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
Abstract: Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors ’ experience, aiming at the treatment orientation of these diseas...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Authors: Juratli HA, Görög A, Sárdy M Abstract Dermatitis herpetiformis (DH) is a genetically determined, gluten sensitive autoimmune bullous dermatosis related to celiac disease in which granular, insoluble aggregates in the papillary dermis of epidermal transglutaminase (TG3), immunoglobulin A (IgA), and fibrinogen are present. Detection of the dermal IgA-TG3 immune complex is the gold standard of diagnosis. DH develops in a subpopulation of patients with gluten sensitive enteropathy, characterized by itching, erythematous, excoriated papules showing characteristic distribution ove...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Because it has become such a frequent item in everyday meals, suggesting that something so commonplace must be fine, people often ask: Is wheat really that bad? Let’s therefore catalog the health conditions that are associated with wheat consumption. Health conditions we know with 100% certainty are caused by consumption of wheat and related grains: Celiac disease, dermatitis herpetiformis, cerebellar ataxia, “idiopathic” peripheral neuropathy, temporal lobe seizures, gluten encephalopathy, type 1 diabetes, rheumatoid arthritis, autoimmune hepatitis, autoimmune pancreatitis, tooth decay Health conditions ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune diabetes gluten-free grain-free grains wheat wheat belly Source Type: blogs
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