Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF- κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms.

CONCLUSIONS: Our data highlight the pivotal function of α7nAChR and intact vagus nerves in protecting against LPS-induced ALI through inhibiting the TLR4/MyD88/NF-κB signaling pathway upon pretreatment with DEX.
PMID: 31520992 [PubMed - as supplied by publisher]

Source: International Immunopharmacology - September 10, 2019 Category: Allergy & Immunology Authors: Zi SF, Li JH, Liu L, Deng C, Ao X, Chen DD, Wu SZ Tags: Int Immunopharmacol Source Type: research