Synthesis and characterization of metallophthalocyanine with morpholine containing Schiff base and determination of their antimicrobial and antioxidant activities

Publication date: Available online 14 September 2019Source: Journal of Organometallic ChemistryAuthor(s): Dilek Unluer, Ayse Aktas Kamiloglu, Sahin Direkel, Ersan Bektas, Halit Kantekin, Kemal SancakAbstractIn this work, novel metallophthalocyanine compounds (M = Zn, Cu, Co) bearing four 2-methoxy-4-{(Z)-[(4-morpholin-4-ylphenyl)imino]methyl}phenol at the peripheral positions were sythesized starting from the new phthalonitrile derivative (2). These new compounds (2–5) have been characterized by a combination of FT-IR, 1H NMR (for compounds 2 and 3), 13C NMR (for compound 2), UV–Vis (for compounds 3,4 and 5) and mass spectrophotometry techniques. Antioxidant activities of the metallophthalocyanines were investigated by using DPPH free radical scavenging assay and FRAP (ferric ion reducing antioxidant power) method. The antimicrobial activity of the synthesized metallo phthalocyanine compounds (3–5) were determined against the selected different six standart bacteria isolates by microdilution broth assay with Alamar Blue Dye. Most affected bacteria from the compounds were standard E. coli and S. typhimurium (MIC 625 μg/ml). Standart Y. enterocolitica and S. aureus have been less affected by the compounds (MIC 10.000 μg/ml).Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research