Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats.

In this study, we found that paeonol reduced the seizure scores of epileptic rats and attenuated the duration and onset latency of seizures. Paeonol can also increase the activities of total antioxidant capacity, SOD and catalase activity and reduce MDA content as well. This suggests that paeonol can improve the level of oxidative stress in rats. More significantly, paeonol can improve neuronal loss and apoptosis in epileptic rats. These results indicate that paeonol has anticonvulsant and neuroprotective effects in epileptic rats. This effect may be caused by reducing oxidative stress. PMID: 31520267 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: WebMD Health - Category: Consumer Health News Source Type: news
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Condition:   Epilepsy, Temporal Lobe Intervention:   Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University Completed
Source: - Category: Research Source Type: clinical trials
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Source: Cell Reports - Category: Cytology Source Type: research
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Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
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Source: - Category: General Medicine Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Environmental Issues, Climate, Geophysics Source Type: news
Authors: Shen CC, Jiang JF Abstract Background: Posttraumatic epilepsy (PTE) is a common complication of traumatic brain injury (TBI), which seriously affects patients' survival and recovery. Vagus nerve stimulation (VNS) is a nonpharmacological therapy for epilepsy. The auricular branch of the vagus nerve (ABVN) is the only peripheral branch and has antiepileptic effects, but the efficacy of ABVN stimulation as treatment of late PTE is uncertain. We retrospectively analyzed the clinical efficacy of ABVN stimulation by auricular electroacupuncture for the treatment of late PTE, and investigated the influence of sod...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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