Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism

Publication date: Available online 14 September 2019Source: Genes &DiseasesAuthor(s): Wei Liu, Zhongliang Deng, Zongyue Zeng, Jiaming Fan, Yixiao Feng, Xi Wang, Daigui Cao, Bo Zhang, Lijuan Yang, Bin Liu, Mikhail Pakvasa, William Wagstaff, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Fang He, Yukun Mao, Huiming Ding, Yongtao ZhangAbstractBone morphogenetic protein 9 (BMP9) (or GDF2) was originally identified from fetal mouse liver cDNA libraries. Emerging evidence indicates BMP9 exerts diverse and pleotropic functions during postnatal development and in maintaining tissue homeostasis. However, the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed. Here, we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice. By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain, adult lungs and adult placenta. We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages. We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice, but decreased in older mice. Interestingly, Bmp9 was only expressed at low to modest levels in developing bones. BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs. Furthermore, the feedback inhibitor Smads Smad6 and Smad7 were widely expressed...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research

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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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