Impact of Renal Function Trajectory on Renal Replacement Therapy and Mortality Risk after Renal Artery Revascularization

Publication date: Available online 14 September 2019Source: Journal of Vascular and Interventional RadiologyAuthor(s): Edwin A. Takahashi, William S. Harmsen, Sanjay MisraAbstractPurposeTo determine the impact of renal function trajectory, defined as the change in renal function over time before and after renal artery stent placement, on long-term risk for renal replacement therapy (RRT) and mortality.Materials and MethodsEstimated glomerular filtration rates (eGFRs) 6–12 months before renal artery stent placement, at the time of intervention, and 6–12 months after intervention were determined in 398 patients. The effect of eGFR change before and after renal artery stent placement was calculated. Cox proportional-hazards ratio was used to determine the risks for RRT and all-cause mortality.ResultsThe risk for RRT was significantly influenced by eGFR change from the time of intervention to follow-up at 6–12 month after treatment (P = .02). In addition, among patients with a postintervention eGFR ≤ 40 mL/min/1.73 m2, for every 1 unit of eGFR increase, there was a significant decrease in RRT and all-cause mortality (P
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research

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This study aimed to clarify the renal status in elderly patients with type 2 diabetes.Participants and methodsThere were 978 patients with type 2 diabetes who were classified into three groups: Group 1 (aged
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Setting aside the mice genetically engineered to destroy senescent cells, the combination of dasatinib and quercetin is the oldest of the senolytic treatments used in animal studies. Senolytic therapies are those that selectively destroy senescent cells in old tissues in order to produce rejuvenation, turning back the progression of numerous age-related conditions. Unusually for early stage research, these initial senolytics are actually quite effective, considered in the grand scheme of things. Thus they have moved directly to human trials in some cases. The first data on their ability to produce the same outcomes in huma...
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Up to 50% of patients with type 2 diabetes have chronic kidney disease (CKD) [1], characterized by steady decline in kidney function leading to end stage renal disease (ESRD). To monitor kidney function, to classify the stages and to decide the treatment, estimated glomerular filtration rate (eGFR) is commonly used. Indication of renal replacement is always based on eGFR, not albuminuria or proteinuria. Therefore, it is crucial to assess eGFR, followed by identifying and treating at-risk patients for progressive kidney disease.
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ConclusionOSA was associated with a higher risk of incident ESRD. Understanding the association between OSA and ESRD might provide further insights to establish national health care policy.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Burnier M, Lin S, Ruilope L, Bader G, Durg S, Brunel P Abstract Objective: Angiotensin receptor blockers (ARB) are among the recommended first-line treatment options in patients with hypertension and chronic kidney disease (CKD). This meta-analysis evaluated the effect of ARB on blood pressure (BP) and renal function in patients with concomitant hypertension and CKD with or without diabetes. Methods: Literature search was performed in PubMed/MEDLINE, EMBASE and BIOSIS to identify parallel-group, randomized controlled trials (≥8 weeks) reporting the effects of ARB on office systolic/diastolic BP (SBP/DBP...
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Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), is common and a risk factor for cardiovascular disease (CVD). The risk rises with decline in eGFR and is maximal (around 20 times that of the general population) in patients with end-stage kidney disease (ESKD) requiring dialysis. Conventional factors such as diabetes mellitus, hypertension, smoking and hyperlipidaemia contribute to the risk of progressive CKD and CVD. Other factors including proteinuria, left ventricular hypertrophy, impaired calcium –phosphate homeostasis (PTH, FGF-23), anaemia and inflammation, contribute to ...
Source: Medicine - Category: Internal Medicine Authors: Tags: Chronic kidney disease Source Type: research
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