Bear Grylls health: ‘That was crazy!’ Survival expert’s life-threatening allergic reaction
BEAR GRYLLS, known for his survival skills in the great outdoors, had to be saved by medics after suffering a life-threatening allergic reaction while filming for his new series. The former SAS serviceman went into anaphylactic shock, which can prove fatal.
ConclusionsFor many patients, at-home administration of omalizumab or mepolizumab may be a cost-effective strategy.
Publication date: Available online 15 October 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Edgardo José Jares, Ricardo Cardona Villa, Sánchez-Borges Mario, De Falco Alicia, Luis Felipe Ensina, Bernstein Jonathan A, Alfredo Arias-Cruz, Ivan Cherrez-Ojeda, Blanca Morfín Maciel, Alejandra Macías-Weinmann, Sandra González Díaz, Dirceu Sole, Pedro Giavina Bianchi, Susana de Barayazarra, Mabel Cuello, Miguel Vinuesa, Juan Carlos Calderón., Viviana A. Zanacchi, Silvana Monsell, Mara Morelo Rocha Felix
Refractory anaphylaxis (unresponsive to treatment with at least two doses of minimum 300 μg adrenaline) is a rare and often fatal hypersensitivity reaction. Comprehensive data on its definition, prevalence, and risk factors are missing. Using the data from the European Anaphylaxis Registry (11,596 cases in total) we identified refractory anaphylaxis cases (n = 42) and analyzed these in comparison to a control group of severe anaphylaxis cases (n = 4,820). The data show that drugs more frequently elicited refractory anaphylaxis (50% of cases, p
AbstractDrugs are one of the major causes of anaphylaxis. For example 2346 cases of drug-induced anaphylaxis were reported to the anaphylaxis register as of March 2019. The most common triggers of drug-induced anaphylaxis were nonsteroidal anti-inflammatory drugs (NSAIDs;n = 902) and antibiotics (n = 721). Drug-induced anaphylaxis can be caused by IgE-dependent (e.g., penicillins) and IgE-independent mechanisms. Recently MRG-PX2 has been identified as a receptor for non-IgE-dependent mechanisms. Drug-induced anaphylaxis results more frequently in lethal reactions and is more commonly as so...
Recent epidemiological studies suggest that non-IgE-mediated childhood food allergic disorders such as eosinophilic esophagitis (EOE), celiac disease and allergic gastroenteritis (AG), may be increasing in parallel with previously observed increases in childhood IgE-mediated food allergy (FA) and food-induced anaphylaxis (FIA)1-4. The term AG encompasses food protein induced enterocolitis syndrome (FPIES), eosinophilic enteritis and colitis, food protein induced enteropathy, food hypersensitivity enteritis and colitis, but not EOE.
CONCLUSION: A patient with HCC was successfully treated with pembrolizumab after experiencing adverse effects with nivolumab. PMID: 31612928 [PubMed - in process]
Abstract Snakebite is one of the health concerns worldwide. Naja oxiana is one of the venomous snakes with a high mortality rate. Anti-serum therapy is the only treatment of the victims. However, in some cases, antiserum injection leads to some side effects in host like serum sickness and anaphylactic shock. It is crucial to develop a neutralizing agent with low side effects. The human antibody library (non-immunized library) was used to isolate specific antibodies against N.oxiana venom components. Four rounds of biopanning were performed to enrich scFv-displaying phages against the venom of N. oxiana. Enrichment...
Publication date: Available online 9 October 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Timothy E. Dribin, Kenneth A. Michelson, Michael C. Monuteaux, David Schnadower, Mark I. Neuman
ConclusionsHistory of penicillin-associated rash (without angioedema, mucosal ulceration, or systemic involvement), more than 1 year ago, is sufficient to select a patient for a direct oral penicillin challenge. This large multicenter study demonstrates that this approach appears safe, and risk is comparable to that in other procedures being performed in primary care in Australia. The higher risk patients are more likely to benefit from skin testing. This simple risk-based delabeling strategy could potentially be used by nonallergists, leading to more efficient penicillin allergy delabeling service provision.
ConclusionsThe trial demonstrated a favorable safety profile of the SQ HDM SLIT tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (ie, short-acting β2-agonist) at baseline in the efficacy assessment using asthma exacerbation during inhaled corticosteroid reduction (JapicCTI number 121847).