Exogenous GM3 ganglioside inhibits atherosclerosis via multiple steps: a potential atheroprotective drug
This study sought to answer the question by investigating exogenous GM3 effects on multiple steps involved in atherogenesis. First, the physicochemical properties of native low-density lipoprotein (LDL) and LDL enriched with exogenous GM3 (GM3-LDL) were characterized by dynamic laser scattering, atomic force microscopy, and agarose gel electrophoresis. Then, electrophoretic mobility, conjugated diene and malondialdehyde production, and amino group blockage of GM3-LDL/LDL were measured to determine LDL oxidation degrees and cellular recognition/internalization of GM3-LDL/GM3-oxLDL were detected via confocal microscopy and flow cytometry. Subsequently, influences of exogenous GM3 addition on the monocyte-adhering ability of endothelial cells and on lipid deposition in macrophages were investigated. Finally, exogenous GM3 effect on atherogenesis was evaluated using apoE-/- mice fed a high-fat diet. We found that exogenous GM3 addition increased the size, charge, and stability of LDL particles, reduced LDL susceptibility to oxidation and its cellular recognition/internalization, impaired the monocyte-adhering ability of endothelial cells and lipid deposition in macrophages. Moreover, exogenous GM3 treatment also significantly decreased blood lipid levels and atherosclerotic lesion areas in atherosclerotic mice. The data imply that exogenous GM3 had an inhibitory effect on atherogenesis, suggesting a protective role of a GM3-enriched microenvironment in atherosclerotic plaques and...
Authors: Hanewinkel R PMID: 31623003 [PubMed - in process]
Zum Kommentar von Prof. Reiner Hanewinkel zum Hot Topic-Thema „Raucherentwöhnung: E-Zigarette besser als klassische Nikotinersatzpräparate?“ Pneumologie 2019; 73: 336 – 337. Pneumologie. 2019 Oct;73(10):622 Authors: Pommer P PMID: 31623002 [PubMed - in process]
Authors: Schulz H, Karrasch S, Bölke G, Cyrys J, Hornberg C, Pickford R, Schneider A, Witt C, Hoffmann B PMID: 31623001 [PubMed - in process]
Leserbrief zu Schulz H, Karrasch S, Bölke G et al. Atmen: Luftschadstoffe und Gesundheit – Teil I. Pneumologie 2019; 73: 288 – 305. Pneumologie. 2019 Oct;73(10):617-619 Authors: Schnitzler A PMID: 31623000 [PubMed - in process]
Authors: Schöll N, Rohde GGU Abstract Pneumonia belongs to the most frequent and most deadly infectious diseases worldwide. It represents an increasing problem for the aging population. The incidence and mortality rises with every decade. The clinical presentation of pneumonia differs between elderly and younger patients. Multiple factors including functional status (self-dependency and immobilization), comorbidities, immunosenescence, nutritional status, swallowing disorders have to be accounted for. Pneumonia in the elderly has to be differentiated from nursing home acquired pneumonia. Diagnosis of pneumonia...
Perikardpunktion – Schritt für Schritt. Pneumologie. 2019 Oct;73(10):597-604 Authors: Ferrari MW PMID: 31622998 [PubMed - in process]
Authors: Raspe M, Rolling T, Leisse C, Fischer J, Lehmann C Abstract Infectious Diseases are a cross-sectional area connected to various medical disciplines and offer interested physicians multiple working opportunities. The spectrum of infectious diseases covers both out- and inpatient care as well as basic, clinical and epidemiological research. The need for infectious diseases specialists is increasing, thus career prospects are promising. Working conditions in infectious diseases are comparatively family-friendly. With this article we intend to arouse interest for working in the fascinating fields of infectious...
Authors: Bahmer T, Wälscher J, Fisser C, Kreuter M, Karg O, Böing S, Koczulla R, Raspe M PMID: 31622996 [PubMed - in process]
Lungengesundheit: Beruf als großer Risikofaktor? Pneumologie. 2019 Sep;73(9):e2 Authors: Simon A PMID: 31622984 [PubMed - in process]
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