New insights into different adipokines in linking the pathophysiology of obesity and psoriasis

Psoriasis is a chronic, systemic, hyper-proliferative immune-mediated inflammatory skin disease. The results of epidemiological investigations have shown that psoriasis affects around 2% of the general populat...
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Review Source Type: research

Related Links:

CONCLUSION: We identified important similarities and differences in the clinical characteristics of adults with psoriasis and AD; these should help clinicians to prioritize and improve patient management. PMID: 31630393 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
CONCLUSION: we show herein that IL-17A does not play a major role in the impairment of adipogenesis and/or insulin resistance mediated by an inflammatory environment, but contributes to the propagation of inflammation in human obese adipose tissues. This suggests a beneficial effect of anti-IL17A mAb in inflammatory pathologies, where obesity contributes to poorer response to biologic treatments. PMID: 31629101 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Eating less processed food and more fruit, vegetables, fish and olive oil improved depression symptoms Related items fromOnMedica Psoriasis linked to raised risk of many mental health problems GPs need more time to treat complex needs Report reveals toll of living with rare diseases Mental health services face double whammy Should we recognise obesity as a disease?
Source: OnMedica Latest News - Category: UK Health Source Type: news
te; E Abstract Psoriasis affects 0.5% of children. The current therapeutic arsenal includes local treatments, phototherapies and systemic treatments (conventional systemic therapy and biotherapy), which, in most cases, are sufficient to control this skin disease. Subsequent management of these children should focus on maintaining therapeutic efficacy and preventing relapse by reducing any treatment-related toxicity in order to improve their quality of life. It would therefore appear useful to adopt a "proactive" attitude. To be proactive is to anticipate disease progression in order to limit both the sev...
Source: Annales de Dermatologie et de Cenereologie - Category: Dermatology Authors: Tags: Ann Dermatol Venereol Source Type: research
Conclusion: Patients with psoriasis expressing the C allele of AT1R1166 are susceptible to developing metabolic syndrome and have higher PASI scores as compared with patients carrying the A allele. PMID: 31571968 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
CONCLUSION: RAPID3 and PSAID12 have excellent construct validity in PsA and are strongly correlated despite differing items. Contextual factors (i.e., the presence of depression and obesity) should be considered when interpreting raw scores of the RAPID3 and PSAID12. PMID: 31575704 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
Psoriasis is a systemic inflammatory disease characterized by overproliferation of keratinocytes and epidermal thickening resulting from dysregulated immune responses.[1,2] This chronic condition, which affects approximately 1% to 4% of the world ’s population, is often associated with comorbidities, including obesity, type 2 diabetes, hyperlipidemia, hypertension, and cardiovascular disease.[3–7] The pathogenesis of psoriasis involves keratinocyte recruitment of myeloid dendritic cells, which produce interleukin (IL)-23 to activate T he lper 17 (Th17) cells.[2,8,9] Th17 cells, in turn, produce several cytokine...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Authors: D'Adamio S, Silvaggio D, Lombardo P, Bianchi L, Talamonti M, Galluzzo M Abstract Introduction: Psoriasis is a chronic inflammatory disease and affects about 10% of the worlds population. Psoriasis is associated with a number of comorbidities. Biologic therapies for the treatment of moderate-severe plaque psoriasis include tumour necrosis factor α inhibitors (TNFi), and newer molecules targeting IL-12 and 23, blocking p40 subunit, or targeting subunit p19 of IL-23 and other molecules blocking IL-17A, or directed against the IL-17 receptor. Areas covered: Anti-interleukin drugs show great improvement i...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
The early impact of apremilast on the quality of life (QoL) and pruritus severity of adult bio-naive patients with moderate psoriasis was examined using the Dermatology Life Quality Index (DLQI), the EuroQol 5-dimensions (EQ-5D) instrument, and a pruritus Visual Analogue Scale (VAS, 10cm). 6-week data from the first 100 eligible patients [mean age: 49.9 years; 71.0% males; 41.0% obese; median disease duration: 8.0 years] that completed 24 weeks of observation (or were previously withdrawn) are presented, using last-observation carried forward missing data imputation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
The efficacy of apremilast on scalp, palmoplantar, and nail psoriasis in moderate psoriatic bio-naive patients after 6 weeks of treatment was assessed. Interim data for the first 100 patients [mean age at baseline (i.e. at apremilast onset): 49.9 years; mean age at diagnosis: 40.3 years; 71.0% male; 41.0% obese; mean Psoriasis Area Severity Index: 12.8; 66.0% previously treated with conventional systemic treatments] are presented, using last-observation-carried-forward imputation. At baseline, 77.6% (76/98), 29.6% (29/98), and 62.5% (60/96) of the patients, had Scalp Physician ’s Global Assessment (ScPGA), Palmoplant...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
More News: Eating Disorders & Weight Management | Epidemiology | Lipidology | Obesity | Psoriasis | Skin