Chondrocyte viability is lost during high-rate impact loading by transfer of amplified strain, but not stress, to pericellular and cellular regions

Deleterious impact loading to cartilage initiates post-traumatic osteoarthritis (OA). While cytokine and enzyme levels regulate disease progression, specific mechanical cues that elucidate cellular OA origins merit further investigation. We defined the dominant pericellular and cellular strain/stress transfer mechanisms following bulk-tissue injury associated with cell death.

Source: Osteoarthritis and Cartilage - September 13, 2019 Category: Rheumatology Authors: Pablo F. Argote, Jonathan T. Kaplan, Alan Poon, Xin Xu, Luyao Cai, Nancy C. Emery, David M. Pierce, Corey P. Neu Source Type: research