First magnetic particle imaging angiography in human sized organs by employing a multimodal < i > ex vivo < /i > pig kidney perfusion system.

First magnetic particle imaging angiography in human sized organs by employing a multimodal <i>ex vivo</i> pig kidney perfusion system. Physiol Meas. 2019 Sep 13;: Authors: Molwitz I, Ittrich H, Knopp T, Mummert T, Salamon J, Jung C, Adam G, Kaul MG Abstract Objective&amp;#13; Magnetic Particle Imaging (MPI) is a new, fast and three-dimensional imaging technique, which is considered promising for angiographies. As available MPI-scanners suffer from restricted spatial resolution and are mostly constructed for small animal imaging, no vessels within one organ have been depicted by MPI, yet. The purpose of this study was to develop an ex vivo organ perfusion system to display vessels within one organ of human size by MPI and to compare the results to an established three-dimensional imaging technique.&amp;#13; &amp;#13; Approach&amp;#13; An ex vivo pork kidney perfusion system compatible to Digital Subtraction Angiography (DSA), Magnetic Resonance Tomography and MPI was developed. DSA was used to exemplarily prove intact vessel structures under ex vivo perfusion in two organs. Perfusion in nine organs was displayed by the three-dimensional imaging techniques Magnetic Resonance Angiography (MRA) and MPI angiography. All visible vessels in MRA and MPI were counted and their number compared between both techniques.&amp;#13; &amp;#13; Main results&amp;#13; The ex vivo organ perfusion system allowed to...
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Physiol Meas Source Type: research