The protective effect of Helicobacter Pylori infection on the susceptibility of multiple sclerosis

This study was aimed to determine the seroprevalence of Hp in MS patients and then investigates pro/anti-inflammatory cytokine levels in MS patients infected with HP and seronegative MS patients. Three hundred eighty-seven patients with MS were included in the study and were adjusted by gender and age to 420 healthy subjects.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research

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Publication date: Available online 9 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Brenda Bertado-Cortés, Claudia Venzor-Mendoza, Daniel Rubio-Ordoñez, José Renán Pérez-Pérez, Lucy Andrea Novelo-Manzano, Lyda Viviana Villamil-Osorio, María de Jesús Jiménez-Ortega, María de la Luz Villalpando-Gueich, Nayeli Alejandra Sánchez-Rosales, Verónica García-Talavera
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSIONS: Paramagnetic rims might be a characteristic MRI finding for MS, and therefore they have potential as an imaging marker for differentially diagnosing MS from NMOSD using 3-T MRI. PMID: 33029961 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
CONCLUSIONS: As the present study was the first investigation on the coagulation status in patients with AA, elevated D-dimer levels in alopecia areata may suggest a deficient coagulation in these patients that may contribute to an increase in the risk of thrombosis. Further studies are needed to evaluate this hypothesis using a larger sample size. PMID: 33034439 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Authors: Cáceres-Perkins W, Cabanillas F, San Vicente G, Rivera-Franceschini C, Sobrino-Najul E, Vega-Vázquez LI, Conde-Sterling D Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are B-cell neoplasms that commonly affect the gastrointestinal (GI) tract, usually the stomach. In most cases, extranodal marginal zone lymphoma (ENMZL) is an indolent disease. Bone marrow involvement is common with MALT lymphoma accompanied by paraproteinemia; such involvement impels disease progression. Here, we present the case of an 82-year-old Hispanic patient with long-standing ENMZL in whom the gastric site...
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: Salim MA, Eftekharian MM, Taheri M, Yousef Alikhani M Abstract BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease that disables Central nervous system (CNS) system. Cytomegalovirus (CMV) probably has an important role in the MS pathology. The infection with helicobacter pylori also is recognized as a protective agent against MS in female. METHODS: Serum samples were isolated and frozen at -70°C. The earlier mentioned anti-virus antibodies and antibacterial antibodies were quantified by Elisa kit. RESULTS: The results showed that IgG antibody average value against cytomegaloviru...
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
In many developed countries, the incidence of autoimmune diseases and allergic/atopic disorders are rapidly increasing. The former is regarded as a T helper (Th)1/Th17 disease while the latter is considered a Th2 disease. It is curious that the incidence of Th1/Th17 and Th2 diseases have increased simultaneously, given that Th1/Th17 cells and Th2 cells counteract each other. This inconsistency is explained by the ‘hygiene hypothesis’.1 Frequent infections in poor sanitary conditions may facilitate the development of the immune effector and immune regulatory systems. Overactivation of effector lymphocytes, macro...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Press releases, Immunology (including allergy), Multiple sclerosis, Connective tissue disease, Musculoskeletal syndromes Editorial commentaries Source Type: research
Conclusions Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the ‘hygiene hypothesis’, a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact that the association between H. pylori seropositivity and MS risk was seen almost exclusively in females requires further investigation.
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: JNNP Patients' choice, Press releases, Immunology (including allergy), Multiple sclerosis Source Type: research
CONCLUSIONS: H. pylori infection exerted some protection against EAE in mice, inhibiting both Th1 and Th17 responses. We provide experimental evidence to suggest that H. pylori may provide protection against immune-mediated diseases such as MS.Disclosure: Dr. Gran has received personal compensation for activities with Biogen Idec as a consultant. Dr. Crooks has nothing to disclose. Dr. Cook has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. O'Brien has nothing to disclose. Dr. Braitch has nothing to disclose. Dr. Kareem has nothing to disclose. Dr. Constantinescu has received personal compensation for activi...
Source: Neurology - Category: Neurology Authors: Tags: MS and CNS Inflammatory Diseases: In Vitro Studies, Experimental, and Animal Models Source Type: research
Conclusions: In summary, we propose here that the immunomodulatory activity of an ancient constituent of the gut microbiota, H. pylori, may be exploited for the prevention and/or treatment of inflammatory bowel diseases.
Source: Inflammatory Bowel Diseases - Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
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