Recent developments in peptide-based SPECT radiopharmaceuticals for breast tumor targeting

Publication date: Available online 13 September 2019Source: Life SciencesAuthor(s): Sajjad Ahmadpour, Seyed Jalal HosseinimehrAbstractBreast cancer deaths occur mainly because of poor diagnosis in early stages that lead to tumor metastasis in advanced stages. Developing a high-sensitive early-stage breast cancer diagnostic tool based on single photon emission computer tomography (SPECT) and positron emission tomography (PET) are urgent. There are several evidences to demonstrate the prominent roles of specific receptors overexpression in tumor initiation and progression of breast cancer. Targeting of specific receptor with radiolabeled biomolecule is a suitable tool for early diagnosis of breast cancer. In recent years, investigators have paid their attention in the development of peptide-based radiopharmaceuticals due to their favorable pharmacokinetics that offer diagnostic applications for breast cancer imaging. Various characterizing techniques permit the preparation of variety of peptides that allow efficiently labeling with clinically useful SPECT radionuclides such as 99mTc, 123I and 111In without compromising biological properties. In this review, we will focus on the recent developments in use of peptide-based SPECT radiopharmaceuticals for breast cancer targeting and imaging.Graphical abstract
Source: Life Sciences - Category: Biology Source Type: research

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Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
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Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
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Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
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Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
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Source: PET Clinics - Category: Radiology Authors: Source Type: research
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