GLCCI1 and STIP1 Variants are Associated with Asthma Susceptibility and Inhaled Corticosteroid Response in a Tunisian Population.

GLCCI1 and STIP1 Variants are Associated with Asthma Susceptibility and Inhaled Corticosteroid Response in a Tunisian Population. J Asthma. 2019 Sep 13;:1-15 Authors: Salhi M, Lahmar O, Salah MO, Banić I, Binghao B, Malik W, Hamzaoui K, Turkalj M, Hamzaoui A Abstract OBJECTIVE: Pharmacogenetic studies have recognized specific genes that highly correlate with response to inhaled corticosteroids (ICS) treatment in asthma patients. Among the genes identified, we selected glucocorticoid-induced transcript 1 (GLCCI1) and stress-induced phosphoprotein 1 (STIP1) to evaluate the impact of these gene polymorphisms on ICS treatment response in Tunisian asthmatics. METHODS: We analyzed four single nucleotide polymorphisms (SNPs): two in GLCCI1 (rs37972 and rs37973), and two in STIP1 (rs2236647 and rs2236648), which are genes associated with susceptibility to asthma and response to ICS in a Tunisian cohort. The SNPs were genotyped using reverse transcriptase polymerase chain reaction (RT-PCR) techniques. RESULTS: This case-control study consisted of 230 adult asthmatic patients and 236 healthy subjects. Seventy-five asthmatics were selected and followed through 12 weeks of routine treatment. The T allele rs2236648 in STIP1 was associated with allergic asthma (OR =0.38, 95%CI =0.20-0.69, p = 0.001). The rs37972 and rs37973 of GLCCI1 were associated with a higher risk of asthma (p 
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research

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ConclusionsBronchodilator dose responsiveness may be useful for phenotyping and may be of utility in practice and future studies focused on asthma outcomes or quantification of treatment responses. In children and adolescents, this phenotype of poor bronchodilator responsiveness may be associated with periods of relatively stable disease yet marked airway constriction in response to triggers, including tobacco smoke, respiratory infections/pneumonia, and aeroallergens.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsThe trial demonstrated a favorable safety profile of the SQ HDM SLIT tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (ie, short-acting β2-agonist) at baseline in the efficacy assessment using asthma exacerbation during inhaled corticosteroid reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsPatients may adapt their ICS use to their current needs without this impacting later RDAC.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
We describe a female diagnosed with non-allergic asthma. On March 24, 2016, examination of the skin-biopsy specimen revealed dense eosinophilic infiltration, and the Fip-1-like 1-platelet-derived growth factor receptor a fusion gene in peripheral blood mononuclear cells was negative. She was diagnosed with idiopathic hypereosinophilic syndrome. She was treated with intravenous methylprednisolone (MPSL), and subsequent oral MPSL. Then, she started to receive a monthly mepolizumab in June 2016, and successfully withdrew from daily use of oral MPSL. The patient has a mother diagnosed with non-allergic asthma. In February 2005...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
CONCLUSION: BT in adults with severe asthma improved ACQ, mini-AQLQ and lung function, but resulted in an increased frequency of unscheduled doctor-visits and rescue courses of OCS and antibiotics. PMID: 31593491 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Our increased understanding of airway inflammation in asthma has resulted in major breakthroughs in the treatment of patients. Following the introduction of anti-inflammatory inhaled corticosteroids in the 1970s, the introduction of biologicals that selectively neutralise the activity of, for example, IgE and interleukin-5, has been a major development in targeting inflammation in subgroups of patients with severe asthma [1]. The development of these biologicals required identification of targets for therapy and proof of concept intervention studies to establish the validity of these targets. This was the result of the com...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
AbstractBackgroundAffecting factors of FeNO in different age groups of asthmatic children are still lack of report.ObjectiveTo evaluate factors associated with FeNO, and the response of FeNO to inhaled steroid in different age groups of asthmatic children with allergic rhinitis.MethodsAsthmatic children aged 5 to 12 years were recruited. FeNO, lung function and bronchial hyperresponsivness (BHR) to methacholine, skin prick testing to a panel of aeroallergens, total Immunoglobulin E (IgE) in serum, and eosinophils in blood were tested. Correlations between FeNO and the measured parameters were assessed. FeNO was measured ag...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 4 October 2019Source: Respiratory InvestigationAuthor(s): Takayuki Yamamoto, Jun Miyata, Makoto Arita, Koichi Fukunaga, Akihiko KawanaAbstractAsthma is an allergic disorder with dominant type 2 airway inflammation, and its prevalence is increasing worldwide. Inhalation of corticosteroids is the primary treatment for asthma along with add-on drugs, including long-acting β2 agonists and/or cysteinyl leukotriene (cys-LT) receptor antagonists, in patients with poorly controlled asthma. Cys-LTs are composed of leukotriene C4 (LTC4), LTD4, and LTE4, which are enzymatically metabolized from...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
Publication date: Available online 3 October 2019Source: SteroidsAuthor(s): Luis M. Montaño, Edgar Flores-Soto, Bettina Sommer, Héctor Solís-Chagoyán, Mercedes PerusquíaAbstractChanges in plasma androgen levels in asthmatic men may be linked to asthma severity, seemingly acting through nongenomic and genomic effects. Nongenomic effects include rapid relaxation of carbachol or antigenic challenge pre-contracted guinea pig airway smooth muscle (ASM) in vitro: testosterone (TES) blocks L-type voltage dependent Ca2+ channels, stored operated Ca2+ channels, inositol 1,4,5-trisphosphate recepto...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
AbstractFor the last three decades, the guidelines for asthma management have supported a stepwise therapeutic approach, based on the administration of controller medications (especially inhaled corticosteroids) complemented by on-demand use of rescue medication. Classically, the rescue medication recommended comprised short-acting β agonists (SABA). Some years ago, the use of Symbicort Maintenance and Reliever Therapy (SMART) demonstrated the benefits of a combination of budesonide-formoterol, an inhaled corticosteroid, and a long-acting β agonist (ICS-LABA) as rescue medication in moderate and severe asthma. Th...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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