A prognostic nomogram for predicting the long-term survival outcome of hypopharyngeal squamous cell carcinoma patients after tumour resection to assist the decision-making of postoperative adjuvant treatment

ConclusionThe newly-developed nomogram can effectively predict the survival outcome of patients with HSCC. According to the novel stratification criteria created, patients stratified as high-risk could benefit from POAT, while those in the low-risk group are advised not to receive POAT as this correlates with a worse OS.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research

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ConclusionsPET/CT was useful for early detection of EPCs. The use of PET/CT for the early detection and treatment of EPCs with no symptoms can improve treatment outcomes.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Conclusions In the span of a very short time—less than a decade—robotic head and neck surgery has transformed the management of the head and neck cancer, and it seems clear that the future of treatment for these cancers lies in a multimodal approach in which TORS is likely to play an important role. Nevertheless, it is important to keep in mind that the current indications for TORS are limited and long-term data on the safety and oncological outcomes are needed to better understand the true role of TORS in treatment of head and neck cancer. Nonetheless, the emergence of ever more advanced robotic instruments i...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study, we compared the diagnostic accuracy of MR imaging and of a combination of weighted-average and iodine overlay dual-energy CT images in detecting cartilage invasion by laryngeal and hypopharyngeal squamous cell carcinomas, in particular thyroid cartilage invasion. MATERIALS AND METHODS: Fifty-five consecutive patients who underwent 3T MR imaging and 128-slice dual-energy CT for preoperative initial staging of laryngeal or hypopharyngeal squamous cell carcinomas were included. Two blinded observers evaluated laryngeal cartilage invasion on MR imaging and dual-energy CT using a combination of weighted-average ...
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: HEAD & amp; NECK Source Type: research
Abstract Various studies have investigated laryngeal function and survival after induction chemotherapy in hypopharyngeal carcinoma, but potential factors to help predict response rates after induction chemotherapy remain unknown. This retro- spective study evaluated which factors are related to an ineffective response to two-cycle docetaxel, cisplatin, and 5-fluoro- uracil (TPF) induction chemotherapy in hypopharyngeal carcinoma to determine potential candidates for this treatment in clinical practice. From Jan 2005 to Dec 2015, 81 patients diagnosed with hypopharyngeal squamous cell carcinoma based on a patholog...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
CONCLUSION: There is a low incidence of thyroid gland involvement in laryngeal carcinoma. Most cases of gland involvement occurred by direct extension. Thyroidectomy during laryngectomy should be considered for advanced stage tumours with cartilage invasion. PMID: 28592347 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
The objective of this study is to analyze the accuracy of computed tomography in detecting malignant thyroid cartilage invasion. In a retrospective chart review, 120 patients with carcinoma of the larynx and hypopharynx underwent computed tomography before total laryngectomy. These data were compared with the histological specimens. Multidetector computed tomography (MDCT) scan had a positive predictive value (PPV) of 76 % and a negative predictive value (NPV) of 69 %. The specificity of MDCT was 89 % and sensitivity was 46 %. Comparison between radiologic suspected cartilage invasion and histologic res...
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Conclusions Invasion of the thyroid gland is uncommon in the context of laryngopharyngeal SCC. Clinical and pathological features such as invasion of the anterior commissure, subglottis and cricoid cartilage are more associated with glandular invasion.
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Head and neck cancer (HNC) ranks fifth among the most common neoplasms, with>500.000 new cases diagnosed every year [1]. HNC comprises a group of malignant tumours located in the upper aero-digestive tract which show similar biological behaviour. The classification of HNC can be based on the anatomic sites of origin (i.e. nasopharynx, nasal cavity, paranasal sinuses, oropharynx, oral cavity, larynx, hypopharynx, salivary glands, thyroid glands) as well as on the histological type, with squamous cell carcinoma being the most frequent type of disease.
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: Our results indicate that SCC of head and neck has a high potential for creating micrometastases which frequency is higher compared to clinically detected macrometastases. Therefore, elective neck dissection or radiotherapy of the neck should be considered in patients with high risk of occult metastases or micrometastases. PMID: 26455568 [PubMed - in process]
Source: Acta Medica: Hradec Kralove - Category: Journals (General) Tags: Acta Medica (Hradec Kralove) Source Type: research
Publication date: Available online 8 May 2015 Source:Egyptian Journal of Anaesthesia Author(s): Adriano Bechara de Souza Hobaika , Cáudia Helena Ribeiro Silva , Nilo Garonci Alves , Wirleide Matos Leão , Núbia Campos Faria Isoni This manuscript describes two cases of thoracic spinal anaesthesia for patients with severe diseases, with satisfying results. Patient 1: female, 57years old, submitted to a surgical gastrostomy. She had squamous cell carcinoma of the hypopharynx involving the C6 vertebra, carotid and thyroid, with a fistula in the cervical region. After sedation, an epidural puncture was per...
Source: Egyptian Journal of Anaesthesia - Category: Anesthesiology Source Type: research
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