The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4+ T Cells.

We present strong evidence that T cells derived from KSRP-/- mice favor Th2-driven immune responses. PMID: 31511826 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

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Publication date: Available online 15 October 2019Source: Journal of Herbal MedicineAuthor(s): Tarun Sharma, Snehasis JanaAbstractBoswellic acids (BAs) are the important active constituents of the plant Boswellia serrata which has been widely used for the treatment of several acute and chronic inflammatory diseases. These acids have shown their very potent anti-inflammatory activities in both in vitro and in vivo animal models. Also, their anti-arthritic, anti-rheumatic, anti-diarrhoeal, anti-hyperlipidemic, anti-asthmatic, anticancer, anti-microbial, analgesic activity, hepatoprotective, and immunomodulatory activities ha...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
BOSTON (CBS) – Many Americans with aching joints are offered steroid injections to help ease their pain, but local researchers say those shots are causing more harm. Steroid injections, often combined with a local anesthetic, are commonly used to treat hip and knee pain associated with osteoarthritis.  Researchers at the Boston University School of Medicine reviewed data on hundreds of joint injections performed in 2018 and found that, in some patients, those shots were associated with acceleration of the arthritis, fractures, and bone loss. The researchers say that, while more study is needed, radiologists and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston Arthritis Boston University School Of Medicine Source Type: news
Publication date: Available online 15 October 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Patrícia Martins, João Eurico FonsecaAbstractMultiple studies have shown that there is a pre-clinical period preceding the development of rheumatoid arthritis (RA). During this period, complex interactions between the environmental and genetic causes occur, and the expression “preclinical RA” has been proposed to define it. Early treatment intervention is associated with less joint damage and has an increased possibility of achieving remission. In this review, we provide an overvie...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
A theme of recent years is the discovery of processes of regrowth that operate in mammalian tissues long thought to be non-regenerative. In this case, researchers have found a mechanism of regeneration that operates in cartilage, albeit not to the degree that would be helpful for recovery from more serious injury or the wear of aging. Still, where a mechanism exists at all, it should be possible to find ways to enhance its operation. This work is interesting for the resemblance that this regenerative process bears to the way in which salamanders regrow lost organ tissue. Finding ways to bring that sort of exceptional regen...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
l;nke G Abstract Mononuclear phagocytes, including monocytes and macrophages, are a central component of the host's innate immune system designated to protect against invading pathogens. However, these cells do not only interact with various parts of the innate and adaptive immune system, but also fulfill indispensable duties during the control of tissue homeostasis and organ function. Moreover, macrophages are crucially involved in tissue remodeling and repair in response to damage. Simultaneously, mononuclear phagocytes might also contribute to the pathogenesis of various inflammatory and autoimmune diseases. In...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
Publication date: Available online 14 October 2019Source: Life SciencesAuthor(s): Gleison Daion Piovezana Bossolani, Bruna Thais Silva, Juliana Vanessa Colombo Martins Perles, Mariana Machado Lima, Flávia Cristina Vieira Frez, Sara Raquel Garcia de Souza, Camila Caviquioli Sehaber-Sierakowski, Ciomar Aparecida Bersani-Amado, Jacqueline Nelisis ZanoniAbstractAimsThe aim of our study was to study the pathological mechanisms induced by the rheumatoid arthritis (RA) on the Enteric Nervous System (ENS).Main methodsWe evaluated the effect of the chronic arthritis and its treatment with 50 mg/kg quercetin alone (AQ) and ...
Source: Life Sciences - Category: Biology Source Type: research
In this study, we found that the water extracts of Boseokchal (BSC-W) inhibited osteoclast differentiation in vitro and investigated its inhibitory mechanism. BSC-W was obtained by extracting flour of Boseokchal using hexane and water. To osteoclast differentiation, bone marrow-derived macrophage cells (BMMs) were cultured with the vehicle (0.1% DMSO) or BSC-W in the presence of M-CSF and RANKL for 4 days. Cytotoxicity was measured by CCK-8. Gene expression of cells was confirmed by real-time PCR. Protein expression of cells was observed by western blot assay. Bone resorption activity of osteoclast evaluated by bone pit fo...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
We report four cases of extensive AA successfully treated with apremilast.
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
ConclusionsVidofludimus demonstrated a positive safety profile, making it a promising candidate for the treatment of a variety of immune-related diseases.Trial RegistrationsClinicalTrials.gov identifier: NCT01010581.
Source: Drugs in R&D - Category: Drugs & Pharmacology Source Type: research
Total elbow arthroplasty (TEA) is a treatment option for end-stage arthritis. Even though results are satisfactory for the elderly population, TEA surgery is subject to controversy in younger patients. The purpose of this study was to evaluate clinical and radiographic outcomes of semiconstrained TEA performed for arthritis in patients younger than 55 years.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
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