Epilepsy deaths in children: Improvements driven by data and surveillance in pediatrics

Publication date: Available online 13 September 2019Source: Epilepsy &BehaviorAuthor(s): Omar Abdel-Mannan, Elaine Hughes, Colin DunkleyAbstractEpilepsy-related death in children and young people deserves understanding and intervention along with epilepsy-related deaths in adults. Risk of death from epilepsy varies at different ages, and the specific calculations of risk remains complex and varies between studies. There have been several UK studies examining factors associated with epilepsy-related deaths. A UK national audit with other national initiatives has evidenced improving quality of care and more recently allowed service provision factors associated with reduced epilepsy-related death to be evidenced. A national program of health education, formalized epilepsy networks, commissioned surgical pathways, and patient information resources around risk and participation are examples of quality improvement initiatives. Epilepsy-related death is a key outcome, and there remains many difficulties and opportunities at local, regional, and national level to better understand and improve this outcome for children and young people and the adults that they should become.This paper is for the Special Issue: Prevent 21: SUDEP Summit - Time to Listen.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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ConclusionThis study shows that psychiatric lifetime diagnoses are associated with worse surgical outcome and highlighted the importance of the inclusion of these diagnoses in the evaluation of the potential success of the surgery.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This study aimed to examine the effect of training given to nursing students using simulation and standard child mannequins on their childhood epileptic seizure management knowledge, skills, and attitudes.MethodsParticipants (n = 72) were recruited from a Nursing Faculty in Izmir, Turkey. Students were randomly assigned to the intervention and control groups (n = 36 in each). The intervention group received simulation-based training on epilepsy while the control group received standard child mannequin training on epilepsy. One week after the training, the students were asked to demonstrate their epileptic seizure m...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionI proposed a new semiological classification system for PNES based on this systematic review. This includes three major classes of motor seizures, nonmotor seizures, and mixed semiology. A universally accepted and appropriate semiological classification system for PNES may lead to better standardization of future studies and may also help in better understanding of the pathophysiological basis of this condition.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionsWe ascertained that HIHARS with AA is a relatively common occurrence in children and most likely represents an age-related nonepileptic phenomenon. When associated with fidgeting or yawning, it can help differentiate this phenomenon from absence seizures. However, recording the concomitant presence of generalized spike wave discharges on the EEG remains essential to confirm the diagnosis of absence seizures.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Authors: Morano A, Palleria C, Citraro R, Nesci V, De Caro C, Giallonardo AT, De Sarro G, Russo E, Di Bonaventura C Abstract Introduction. Epilepsy is a common neurological disease requiring complex therapies, which have been unable to achieve seizure control in 30% of patients. Poor adherence has been recognized as a possible determinant of drug-resistance. Prolonged-release formulations of anti-epileptic drugs might help increase adherence, minimize side effects and pharmacological interactions. Areas Covered. Pregabalin (PGB) has peculiar pharmacodynamics and almost ideal pharmacokinetics, except for a short half-l...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
The objective of this study was to investigate the effect of a multidisciplinary program on anxiety, depression, medication adherence, and quality of life in patients with epilepsy in eastern China.MethodsA cohort of 184 patients with epilepsy from the epilepsy clinic of a tertiary hospital in eastern China completed this program, out of which 92 were randomized into the intervention group and 92 the control group. Patients in both groups received standard antiepileptic drugs (AEDs), while those of the intervention group received an additional 12-month multidisciplinary program developed by a group of the epileptologist, p...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 18 October 2019Source: Epilepsy &BehaviorAuthor(s): Jerome Niquet, Lucille Lumley, Roger Baldwin, Franco Rossetti, Mark Schultz, Marcio de Araujo Furtado, Lucie Suchomelova, David Naylor, Ireri Franco-Estrada, Claude G. WasterlainAbstractThe transition from single seizures to status epilepticus (SE) is associated with malaptive trafficking of synaptic gamma-aminobutyric acid (GABAA) and glutamate receptors. The receptor trafficking hypothesis proposes that these changes are key events in the development of pharmacoresistance to antiepileptic drugs (AEDs) during SE, and that blocking t...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of the Special Issue “NEWroscience 2018"
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Discussion -Polymicrogyria is one of the most common malformations of cortical developmentin which the process of normal cerebral cortical development is disturbed late in the stage of neuronal migration or early in the stage of cortical organization, thus considered a disorder of neuronal organization.1. Causes - Congenital infection (particularly cytomegalovirus infection).              - Localized or diffuse in utero ischemia.              - Mutations.2. Clinical profile - ranging f...
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs
ConclusionPrescribing extended-release phenytoin showed the lowest total budget impact in Thailand. A healthcare policy recommendation developed from this research would help in solving the antiepileptic drug issue.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
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