Prevalence of anti-tissue transglutaminase antibodies in patients with irritable bowel syndrome in Duhok city

ConclusionThe prevalence of anti tTG antibodies in irritable bowel syndrome is high. Patients with D-IBS should be screened for celiac disease.ResumoIntroduçãoA síndrome do intestino irritável (SII) é um distúrbio gastrointestinal comum; a doença celíaca é uma enteropatia autoimune que pode imitar qualquer distúrbio gastrointestinal funcional. O objetivo deste estudo foi estimar a prevalência de anticorpos contra a doença celíaca (antitransglutaminase tecidual - tTG) em pacientes com SII.Pacientes e MétodosEste estudo transversal foi conduzido em 70 pacientes com síndrome do intestino irritável que atendiam aos critérios de Roma III e se apresentaram ao Hospital de Ensino Azadi na cidade de Duhok, no Iraque. Os pacientes foram classificados de acordo com os subtipos de síndrome do intestino irritável em: predominantemente diarreia (D-SII), predominantemente constipação (C-SII) e mista (M-SII). IgA e IgG antitTG foram usados para rastrear pacientes com doença celíaca.ResultadosUm total de 70 pacientes (44 mulheres e 26 homens) foram incluídos; a idade média foi de 33 anos (DP ± 7,64). Cinco pacientes (7,1%) apresentaram IgA e IgG antitTG positivos. Três deles tinham D-SII e os outros dois tinham C-SII. Nenhum dos pacientes com M-SII apresentou teste positivo.ConclusãoA prevalê...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research

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Abstract Regulatory T cells (Tregs) play a central role in the induction and maintenance of immune homeostasis and self-tolerance. Tregs constantly express the high-affinity receptor to IL-2. IL-2 is a pleiotropic cytokine and a key survival factor for Tregs. It maintains Tregs' suppressive function by promoting Foxp3 expression and subsequent production of immunoregulatory cytokines. Administration of low-dose IL-2 is shown to be a promising approach to prevent allograft rejection and to treat autoimmune and inflammatory conditions in experimental models. The combination of IL-2 with its mAb (JES6-1) has also bee...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
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Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
CONCLUSION: Education and counselling should be provided by primary healthcare institutions to the families who are part of groups at risk for constipation. It is also suggested that studies should be conducted to increase parents' knowledge and awareness of constipation. PMID: 31738856 [PubMed - in process]
Source: Rural and Remote Health - Category: Rural Health Tags: Rural Remote Health Source Type: research
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Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Case Review Source Type: research
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Source: Health News from Medical News Today - Category: Consumer Health News Tags: Constipation Source Type: news
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Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Dragonfly will use its TriNKET™ platform to develop drug candidates directed to multiple targets for autoimmune disorders, and oncology. AbbVie receives exclusive options to license a number of Dragonfly's natural killer (NK) cell engager immunotherapies.... Biopharmaceuticals, Oncology Dragonfly Therapeutics, AbbVie, TriNKET
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusion: The GFD-PCS measures patient-perceived dietary competence for maintaining a GFD. The scale is psychometrically robust and provides a useful tool in assessing patients' difficulties with a GFD. PMID: 31738623 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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