Hybrid central odontogenic fibroma and central giant cell granuloma lesion – A case report of an aggressive and recurrent lesion

We present a case of a hybrid lesion of COF and CGCG. The lesion presented as a radiolucent lesion of the left mandible that caused bony expansion and paresthesia. Microscopic examination revealed a florid population of fibrohistiocytic cells and multinucleated giant cells in a densely collagenized fibrous connective matrix. Interspersed among this proliferation, lobular collections of intensely basophilic cells with benign cytologic appearance were observed. Immunohistochemistry staining with MCK, Calretinin, CK5/6, and CD68 separated these islands of odontogenic cells from the surrounding multinucleated giant cells and histiocytes. Careful review of previously reported cases appears to yield a relationship with previous long-term history of dental extraction in the area. Management reports in the literature suggest the possibility of a slightly more aggressive lesion than pure central giant cell granuloma, with the possibility of recurrence. Therefore, close clinical follow-up is advised. The possibility of hyperparathyroidism should also be ruled out.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research