Study of the Relationship between ERCC1 Polymorphisms and Response to Platinum-based ...

This study was designed to evaluate the effect of excision repair crosscomplementing group 1 (ERCC1) rs11615 codon 118C/T gene polymorphisms ontreatment outcomes in Iranian patients receiving oxaliplatin-based regimens forcolorectal (CRC) and gastric cancers (GC). Patients, who were candidates to receiveoxaliplatin-based chemotherapy, entered into the study. In 2-week intervals, thepatients received combination regimen of oxaliplatin, fluorouracil, and leucovorin(FOLFOX) for 3 months. ERCC1 rs11615 codon 118C/T polymorphism was testedby restriction fragment length polymorphism polymerase chain reaction (RFLPPCR)method using patients’ peripheral blood lymphocytes. The tumor response tochemotherapy was evaluated by examining the size of the tumor using CT scan.Association between response rates, according to the RECIST criteria, and patients’genotypes was evaluated. Any relationship between response rate and possibleexplanatory factors was also determined. Overall, 40 patients (13 females (32.5%),and 27 males (67.5%)) enrolled in the study. Four patients (10.0%) carried the homozygousmutation (T/T genotype), ten patients (25.0%) were heterozygous (C/Tgenotype), and twenty-six patients (65%) were homozygous (C/C genotype).Response rate were 30.77%, 20.00%, and 0.00% for the genotypes C/C, C/T, andT/T, respectively. No significant association between response rate and genotypeswas observed (p = 0.64). Patients with well- and moderately-differentiatedhistological grade...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 9 December 2019Source: European Journal of Integrative MedicineAuthor(s): Xiao-Qing Wang, Pei-Bei Duan, Man Zheng, Qian Xu, Li-Hua Yang, A-Qin WangAbstractIntroductionAuricular acupuncture has been used for pain management. A more recent technique which buries an intradermal needle into the skin may provides long lasting stimulation and enhance analgesia. The purpose of this study was to evaluate the efficacy and feasibility of perioperative auricular acupuncture technique via intradermal needling buried on postoperative movement-evoked pain reduction of patients with advanced gastric can...
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
(American Gastroenterological Association) This guideline will aid health care provider decision-making for patients who are undergoing upper endoscopy in North America
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study was aimed to investigate the mechanis...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Conclusion.Detection of CDK12‐LOF genomic alterations and their association with FTDs in a diverse spectrum of malignancies suggests that immunotherapy approaches targeting FINAs derived from CDK12‐associated FTDs may be a broadly applicable strategy that could be explored across cancer types in a tumor‐agnostic manner.Implications for Practice.CDK12 inactivation in ovarian and prostate cancer results in the generation of focal tandem duplications, which can cause fusion‐induced neoantigens. In prostate cancer, CDK12 alterations have demonstrated promise as a potential predictive biomarker for response to immune ch...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Cancer Diagnostics and Molecular Pathology Source Type: research
Cancers, Vol. 11, Pages 1987: Phase 1 Dose Escalation Study of the Allosteric AKT Inhibitor BAY 1125976 in Advanced Solid Cancer—Lack of Association between Activating AKT Mutation and AKT Inhibition-Derived Efficacy Cancers doi: 10.3390/cancers11121987 Authors: Andreas Schneeweiss Dagmar Hess Markus Joerger Andrea Varga Stacy Moulder Apostolia M. Tsimberidou Cynthia Ma Sara A. Hurvitz Christine Rentzsch Marion Rudolph Silke Thiele Oliver Boix Gary Wilkinson Eleni Lagkadinou Matthias Ocker This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractThe oncogenic role ERBB2 amplification is well established in breast and gastric cancers. This has led to the development of a well‐known portfolio of monoclonal antibodies and kinase inhibitors targeting the ERBB2 kinase. More recently, activating mutations in the ERBB2 gene have been increasingly reported in multiple solid cancers and were shown to play an oncogenic role similar to that of ERBB2 amplification. Thus, ERBB2 mutations define a distinct molecular subtype of solid tumors and serve as actionable targets. However, efforts to target ERBB2 mutation has met with limited clinical success, possibly because...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Precision Medicine Clinic: Molecular Tumor Board, Cancer Diagnostics and Molecular Pathology Source Type: research
AbstractBackground.Gastric cancer (GC) is a heterogeneous disease, and substantial efforts have been made to develop a molecular biology‐based classification system for GC. Analysis of the genomic signature is not always feasible, and thus, we aimed to (i) develop and validate a practical immunohistochemistry (IHC)‐ and polymerase chain reaction (PCR)‐based molecular classification of GC and (ii) to assess HER2 status according to this classification.Materials and Methods.A total of 894 consecutive patients with GC from two individual cohorts (training, n = 507; validation, n = 387) were classified using Epstein‐Ba...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Cancer Diagnostics and Molecular Pathology, Gastrointestinal Cancer Source Type: research
BOSTON (CBS) — According to a new study published in the journal Cancer, even light to moderate alcohol intake has been linked to a higher risk of cancer. Researchers at the University of Tokyo and the Harvard T.H. Chan School of Public Health looked at data on over 60,000 cancer patients in Japan. They found drinking as little as one drink a day for 10 years or two drinks a year for five years, was associated would increase overall cancer risk by five percent, such as cancers of the colon, stomach, breast, prostate, and esophagus. Cancer risk was lowest with no alcohol consumption.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Cancer Dr. Mallika Marshall Drinking Source Type: news
Conditions:   Gastric Cancer;   Intestinal Metaplasia of Gastric Mucosa;   Helicobacter Pylori Infection;   Atrophic Gastritis Intervention:   Sponsor:   Stanford University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Associations between drinking and cancer were particularly strong for cancers of the mouth, throat, stomach and colon.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alcoholic Beverages Cancer Source Type: news
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