Efficacy of the Topical Calcineurin Inhibitors Tacrolimus and Pimecrolimus in the Treatment of Vitiligo in Infants Under 2  Years of Age: A Randomized, Open-Label Pilot Study

ConclusionsTopical tacrolimus ointment 0.03% or pimecrolimus cream 1% have efficacy for vitiligo in infants, which serves to achieve an appropriate level of safety and tolerability during the 6-month period of applications. Thus, TCIs proved to be a therapeutic option for vitiligo in infants under 2  years of age.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research

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Authors: Cammarata E, Giorgione R, Graziola F, Gironi LC, Zavattaro E, Savoia P PMID: 33026217 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
AbstractTo discuss the advantages and limitations of hair follicle-derived cell transplantation (FCT) in vitiligo, compared to the epidermal cell transplantation (ECT), and the knowledge gap which is required to be bridged. The papers relevant to the purpose was reviewed. Surgical approaches for treating vitiligo are based on the idea of replenishing lost melanocytes. Skin and hair follicles as the main sources of melanocytes have been applied for this purpose transferring the whole tissue or tissue-derived cell suspension to the vitiligo lesions. Considering the differences between hair follicle and epidermis in terms of ...
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research
Conditions:   Vitiligo;   Excimer Laser;   Fractional CO2 Laser Interventions:   Drug: Topical travoprost 0.004% solution;   Device: Fractional CO2 laser;   Device: Excimer laser;   Other: Combination therapy Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Impact of vitamin D receptor gene polymorphisms on vitiligo susceptibility and clinical features in a Southeastern European Caucasian population. Int J Mol Med. 2020 Nov;46(5):1899-1907 Authors: Katsarou MS, Sidiropoulou P, Ieronymaki D, Mastraftsi S, Sifaki M, Xenos K, Nosyrev A, Kovatsi L, Spandidos DA, Lagiou M, Dagklis C, Gregoriou S, Tagka A, Rigopoulos D, Drakoulis N, Nicolaidou E Abstract An association of vitamin D receptor (VDR) polymorphisms and vitiligo has been suggested. However, previous studies have reported contradictory results while including limited data among Ca...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
CONCLUSION: Combination treatment with home-based hand-held NB-UVB plus TCS is likely to be superior to TCS alone for treatment of localised vitiligo. Combination treatment was relatively safe and well tolerated but was only successful in around a quarter of participants. PMID: 33006767 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Publication date: July–September 2020Source: Journal of Ayurveda and Integrative Medicine, Volume 11, Issue 3Author(s): Mohd Shadab, Shariq Shamsi
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
With regard to the article in the February 2020 issue entitled “Activated NLR family pyrin domain containing 3 (NLRP3) inflammasome in keratinocytes promotes cutaneous T-cell response in patients with vitiligo” (J Allergy Clin Immunol 2020; 145:632-45), the authors report that in Fig 3, A, the immunofluorescence staining pictures for the TRPM2 (Stable vitil igo and Active progressive vitiligo) were incorrectly presented. The error did not impact the analysis, results, or conclusions of the article.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Corrigendum Source Type: research
CONCLUSION Room temperature trypsinization can be used as a convenient substitute to warm trypsinization. Cold trypsinization is not recommended because of its poor results and poor patient satisfaction.
Source: Dermatologic Surgery - Category: Dermatology Tags: Original Article Source Type: research
ancillas Vitiligo is a hypopigmentary skin pathology resulting from the death of melanocytes due to the activity of CD8+ cytotoxic lymphocytes and overexpression of chemokines. These include CXCL9, CXCL10, and CXCL11 and its receptor CXCR3, both in peripheral cells of the immune system and in the skin of patients diagnosed with vitiligo. The three-dimensional structure of CXCR3 and CXCL9 has not been reported experimentally; thus, homology modeling and molecular dynamics could be useful for the study of this chemotaxis-promoter axis. In this work, a homology model of CXCR3 and CXCL9 and the structure of the CXCR3/G&...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, we combined heat stress pretreatment with UVB to evaluate whether heat stress pretreatment has an ameliorative effect on UVB-induced damage. Human primary melanocytes (HMCs) were cultured and irradiated with a 308-nm laser with/without heat treatment. MTT assay, apoptosis analysis, and comet assay were conducted to monitor the damage of HMCs. Western blot and immunofluorescence staining were performed to assess the expression and subcellular localization of HSP70. HMCs heated at 42  °C for 1 h exhibit no cytotoxicity. Furthermore, preheat treatment attenuated the UVB laser-induced injury, reduc...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
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