Sensory alteration patterns in burned patients

ConclusionsOur results suggest that burn patients have a sensitivity dysfunction in postburned skin areas. The use of QST could be considered the technique to determine the sensitivity of burned patients. Although, more high-quality studies should to be done.
Source: Burns - Category: Dermatology Source Type: research

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We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Reduced saliva SP concentrations may predict early pharyngeal swallowing dysfunction in PD patients. This finding supports the hypothesis that an impaired SP mediated neurotransmission has a significant impact for the development of dysphagia in PD patients. Larger studies are needed to confirm SP as a clinical useful biomarker for early detection of PD-related dysphagia. Introduction Following Alzheimer's disease, Parkinson's disease (PD) is the second most common neurodegenerative disorder (1, 2). Oropharyngeal dysphagia is a clinically relevant symptom in affected patients as the majori...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Characteristics and nonverbal behaviors of experimenters/clinicians contribute to the elicitation and modulation of pain, placebo, and nocebo effects.IntroductionThe present qualitative review investigated whether the characteristics or nonverbal behavior (NB) of the person administrating painful stimulation affected pain or placebo/nocebo effects in the research participant. The placebo effect is a psychobiological response that may occur following the application of active and inactive interventions (1). Applying an inactive medication paired with positive information about its analgesic effects can reduce pa...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology &Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzheimer&...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
“Find a place inside where there’s joy, and the joy will burn out the pain.” – Joseph Campbell I am certainly not unique in my experience of pain. Like physical scars — of which I have plenty — pain of any kind tends to hang around doing its dirty work until the one suffering takes appropriate action to help dispel it. Granted, some physical pain can only be ameliorated, not eradicated. That’s good enough in some instances, although not ideal. Having gone through numerous instances where I’ve suffered intense physical pain, some of it chronic, as well as emotional pain c...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Health-related Mindfulness Peer Support Personal Self-Help Chronic Pain Emotional Pain healing surgery Source Type: blogs
When a doctor in your hospital system kills himself, the entire medical staff receives a mass email informing everyone of “Dr. So-and-So’s sudden unexpected death”. Thoughts and prayers for his family and loved ones. Perhaps a link to your Employee Assistance Program is provided, for those who may need counseling or grief assistance.  This is followed later that day with another email detailing the schedule for the final arrangements. Calling hours. Funeral. Directions to the church.Not everyone will have known the physician. So most scan the email and then go about thei...
Source: Buckeye Surgeon - Category: Surgery Authors: Source Type: blogs
Conclusions Scalp nerve block is considered an excellent choice for postoperative pain control with less need for opioid analgesia.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
By Crabby McSlacker As a greedy, gadget-obsessed health blogger, I was pretty psyched to get the opportunity to review theLifetrak Zoom HRV Zoom HRV activity tracker. (And, full disclosure: I got to keep it).The Zoom measures a wide variety of activity metrics from your wrist (or ankle, or forearm). What you donot need to use the Zoom: a chest strap!So I've been testing the Zoom out for a couple of weeks in true Crabby McSlacker style: misunderstanding instructions, forgetting to hit "record" to begin or end my workouts, failing to appreciate the nuances, and finding myself too lazy for a comprehensive data compa...
Source: Cranky Fitness - Category: Consumer Health News Authors: Source Type: blogs
It’s just a regular day. Maybe things are going great. Or at least OK. And you feel pretty good. Then something happens. You make a mistake. A setback slips out from around a corner and hits you between the eyes. Or you fall into a rough patch, a crisis or feel that you’re too far away from achieving your dream and you just want to pack up and go home. This week’s article is about those times. And about motivating you, recharging you and staying strong when you need to. Here’s 74 of the most though-provoking, encouraging and helpful quotes on strength and making it through tough times from the last ...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - Category: Consumer Health News Authors: Tags: Happiness Personal Development Success Source Type: blogs
CONCLUSION: Patients with resistant hypertension who underwent RDN in our department had a significant reduction in BP 6 months after the intervention. (123)I-MIBG was not useful in predicting RDN response. Dexmedetomidine and remifentanil provided sufficient patient comfort during the procedure, allowing an adequate number of ablations per renal artery to be performed, and this could probably lead to improved RDN results. PMID: 27583041 [PubMed]
Source: Open Cardiovascular Medicine Journal - Category: Cardiology Tags: Open Cardiovasc Med J Source Type: research
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