Identification of N,N’,N’’-Triacetylfusarinine C as a key metabolite for Root Rot disease virulence in American Ginseng

ConclusionsThe identification of the siderophore produced by Ilyonectria gives us further insight into the root rot disease that heavily affects ginseng crop yields. This research identifies a molecular pathway previously unknown for ginseng root rot and could lead to new disease treatment options.Graphical abstract
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research

Related Links:

Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events.
Source: Journal of Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Authors: Tags: Case report Source Type: research
Debourgogne The current rise in invasive fungal infections due to the increase in immunosuppressive therapies is a real concern. Moreover, the emergence of resistant strains induces therapeutic failures. In light of these issues, new classes of antifungals are anticipated. Therefore, the plant kingdom represents an immense potential of natural resources to exploit for these purposes. The aim of this review is to provide information about the antifungal effect of some important essential oils, and to describe the advances made in determining the mechanism of action more precisely. Finally, the issues of toxicity and r...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
AbstractFungi are responsible for around 20% of microbiologically documented infections in intensive care units (ICU). In the last decade, the incidence of invasive fungal infections (IFI), including candidemia, has increased steadily because of increased numbers of both immunocompromised and ICU patients. To improve the outcomes of patients with IFI, intensivists need to be aware of the inherent challenges. This narrative review summarizes the features of routinely used treatments directed against IFI in non-neutropenic ICU patients, which include three classes of antifungals: polyenes, azoles, and echinocandins. ICU pati...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Tinea capitis, also called scalp ringworm, is a fungal infection. People may sometimes confuse it with other scalp conditions. Learn about its causes, symptoms, and treatments here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Dermatology Source Type: news
Abstract Emerging infectious diseases (EIDs) are a severe problem caused by fungi in human and plant species across the world. They pose a worldwide threat to food security as well as human health. Fungal infections are increasing now day by day worldwide, and the current antimycotic drugs are not effective due to the emergence of resistant strains. Therefore, it is an urgent need for the finding of new plant-origin antifungal peptides (PhytoAFPs). Huge numbers of peptides were extracted from different plant species which play a protective role against fungal infection. Hundreds of plant-origin peptides with antif...
Source: Amino Acids - Category: Biochemistry Authors: Tags: Amino Acids Source Type: research
Post-traumatic fungal infections are an uncommon (2-17% of all fungal infections are post-traumatic), yet life threatening complication secondary to major traumatic injury, that develop when fungal spores inoculate damaged tissue at the injury or wound site, leading to aggressive proliferation of spores and potential angioinvasion. [1-5] Sometimes characterized as a concomitant condition of a major traumatic injury, post-traumatic fungal infections can compromise the immune system, rapidly causing vessel thrombosis and tissue necrosis from a wound site or systemically.
Source: Injury - Category: Orthopaedics Authors: Source Type: research
Abstract Manogepix (MGX) targets the conserved fungal Gwt1 enzyme required for acylation of inositol early in the glycosylphosphatidylinositol (GPI) biosynthesis pathway. The prodrug fosmanogepix is currently in clinical development for invasive fungal infections. We determined that the median frequencies of spontaneous mutations conferring reduced susceptibility to MGX in Candida albicans, C. glabrata, and C. parapsilosis ranged from 3 x 10-8 to
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Antimicrobial peptides (AMPs) represent the largest group of endogenous compounds and serves as a novel alternative to traditional antibiotics for the treatment of pathogenic microorganisms. Moricin is an important α-helical AMP plays a crucial role in insect humoral defense reactions. The present study was designed to identify and characterize novel AMP moricin (Px-Mor) from diamondback moth (Plutella xylostella) and tested its activity against bacterial and fungal infection including the opportunistic human pathogen Aureobasidium pullulans. Molecular cloning of Px-Mor using rapid amplification of cDNA ends revealed...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Purpose of review Viral and fungal infections cause significant morbidity and mortality following hematopoietic stem-cell transplantation (HSCT), primarily due to the prolonged and complex immunodeficient state that results from conditioning chemo-radiotherapy and subsequent prophylaxis of graft vs. host disease. Although currently available antimicrobial pharmacotherapies have demonstrated short-term efficacy, their toxicities often preclude long-term use, and cessation if frequently associated with recurrent infection. Adoptive cell therapy (ACT) offers the potential to more rapidly reconstitute antimicrobial immune re...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: HEMATOLOGIC MALIGNANCIES: Edited by Miguel A. Sanz Source Type: research
Candida is a genus of yeasts that can be a part of normal human skin flora, but may cause disease when the skin barrier is compromised. C. albicans is the most common pathogenic species of this genus, but in recent years infection with other species, such as C. parapsilosis has been growing. C. parapsilosis is a species of Candida that has been found in the skin of humans and other mammals, including dogs. In this brief report, the authors describe two cases of atypical periorifical infection with C. parapsilosis in patients who both volunteered in dog shelters. Owing to the atypical presentation of the fungal infections, ...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
More News: Canada Health | Complementary Medicine | Fungal Infections | Ginseng | Iron