New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum

Publication date: September 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 9Author(s): Cai-Feng DING, Zhi DAI, Hao-Fei YU, Xu-Dong ZHAO, Xiao-Dong LUOAbstractSeven new isoquinoline alkaloids, 9-(2′-formyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2′-formyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2′-formyl oxohernandalin (3), (−)-9-(2′-methoxycarbonyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (4), (−)-2′-methoxycarbonyl thaliadin (5), (−)-9-(2′-methoxyethyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (6), (−)-3-methoxy hydroxyhernandalinol (7), together with six known isoquinoline alkaloids (8–13) were isolated from the roots of Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic measurements. Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells (GSC-3# and GSC-18#) with IC50 values ranging from 2.36 to 5.37 μg·mL−1.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research