Impact of aging on semiquantitative uptake parameters in normal rated clinical baseline 123IIoflupane single photon emission computed tomography/computed tomography

Objectives Studies investigating the age-related impact on dopamine transporter binding have previously omitted the use of attenuation correction by computed tomography (CT). We aimed to explore the impact of age and gender on dopamine transporter binding on [123I]Ioflupane single photon emission CT (SPECT) imaging with simultaneously acquired CT. Methods Three hundred forty-two patients with clinically uncertain parkinsonian syndrome underwent [123I]-Ioflupane SPECT/CT with CT-based attenuation correction. Two nuclear medicine physicians independently performed a visual evaluation of all scans and only visibly normal scans were included for further analysis. Moreover, the results of a fully automatic semiquantitative evaluation method were recorded. Thereafter, the obtained [123I]Ioflupane binding ratio and the hemispheric asymmetry index were correlated with age and sex. Results Patient age range was 41–80 years with a balanced distribution over decades. Of 342 patients, 133 (38.9%, 66 females, median age, 64 years) were considered visually normal by both observers on the SPECT/CT images. A significant inverse correlation between age and [123I]Ioflupane binding ratios in the striata (R = −0.38; P 
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research

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ConclusionsWe suggest SPECT/CT as the primary modality of choice for the assessment of the ratio of diseased lung area. Both perfusion scan and SPECT/CT can be used for the prediction of postoperative lung function.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Publication date: Available online 9 November 2019Source: Epilepsy &BehaviorAuthor(s): Kristie Bauman, Orrin Devinsky, Anli A. LiuAbstractCareful study of the clinical outcomes of temporal lobe epilepsy (TLE) surgery has greatly advanced our knowledge of the neuroanatomy of human memory. After early cases resulted in profound amnesia, the critical role of the hippocampus and associated medial temporal lobe (MTL) structures to declarative memory became evident. Surgical approaches quickly changed to become unilateral and later, to be more precise, potentially reducing cognitive morbidity. Neuropsychological studies foll...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionsUpregulated amygdalar metabolism is associated with an enhanced inflammatory state in female patients with impaired cardiac function. Given that enhanced activity of the limbic system is associated with worse cardiovascular outcomes, our study suggests that a focus on inflammatory markers and indicators of distress might help to tailor cardiovascular risk assessment and therapy towards the female cardiovascular phenotype.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Unilateral condylar hyperplasia (UCH) is characterized by an overgrowth of the mandibular condyle responsible for a facial and dental asymmetry associated with temporomandibular joint function and maxillary growth consequences. The diagnosis is based on a body of clinical, radiological and histological arguments. A 38 years old woman with a reactivation of UCH after a latency period of 16 years following an orthognathic surgery performed for facial asymmetry normalization is presented. She was addressed to our department for a facial progressive asymmetry relapse and dental prosthetic consequences. The radiological images...
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Brief Clinical Studies Source Type: research
Conclusion: In papillary thyroid carcinoma I-131 post-ablation SPECT/CT scan detects cervical lymphadenopathy and predicts relapse by NM stage more accurately than WBS.
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
Publication date: Available online 13 October 2019Source: Radiation Physics and ChemistryAuthor(s): M. Alkhorayef, Fareed H. Mayhoub, Hassan Salah, A. Sulieman, H.I. Al-Mohammed, M. Almuwannis, C. Kappas, D.A. BradleyAbstractDuring the preparation of radioisotopes, during their administration and during patient imaging nuclear medicine personnel are routinely exposed to ionising radiation. With radiation risks increasing with dose, safety assessment is required in seeking to ensure practice complies with international guidelines and dose limits. A particular aim herein is to measure staff exposures during certain molecular...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
Conclusions The quantitative-gated SPECT and quantitative perfusion SPECT values obtained from images with shorter acquisition times correlated with the values obtained from images with a reference acquisition time of 65 s/view; however, tracer-specific predisposition should be considered. These findings suggest that it is possible to reduce acquisition time when performing simultaneous 99mTc-tetrofosmin/123I-β-methyl-p-iodophenyl pentadecanoic acid dual-tracer imaging with the novel cadmium–zinc–telluride scanner.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
AbstractObjectiveQualitative interpretation in bone scan is often complicated by the presence of degenerative joint disease (DJD), especially in the elderly patient. The aim of this study is to compare objectively99mTc-MDP tracer uptake between DJD and osseous metastases of the spine using semi-quantitative assessment with SPECT SUV.MethodsBone scan with SPECT/CT using99mTc-MDP was performed in 34 patients diagnosed with prostate carcinoma. SPECT/CT was performed based on our institutional standard guidelines. SUVmax based on body weight in 238 normal vertebrae visualized on SPECT/CT was quantified as baseline. A total of ...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
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Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
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Source: Pediatric Radiology - Category: Radiology Source Type: research
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