Innate and adaptive effects of inflammasomes on T cell responses.
Innate and adaptive effects of inflammasomes on T cell responses. Curr Opin Immunol. 2013 Mar 7; Authors: Dostert C, Ludigs K, Guarda G Abstract Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8(+) T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies. PMID: 23478069 [PubMed - as supplied by publisher]
U.S. President Donald Trump will seek $2.5 billion from Congress to fight the coronavirus epidemic and U.S. and South Korean militaries are considering scaling back joint training as the virus spreads in Europe and the Middle East.
The Trump administration is asking Congress for $2.5 billion to fight the fast-spreading coronavirus, including more than $1 billion for vaccines, the White House said on Monday.
In a video posted on Monday, Siebel Newsom is seen talking with protesters about the vaccine laws signed by Gov. Gavin Newsom last year before she asks that they not post the video online.
Boston-based biotech start-up uses new technique to speed development
Today, vaccinologists have come to understand that the hallmark of any protective immune response is the antigen. However, it is not the whole antigen that dictates the immune response, but rather the various parts comprising the whole that are capable of influencing immunogenicity. Protein-based antigens hold particular importance within this structural approach to understanding immunity because, though different molecules can serve as antigens, only proteins are capable of inducing both cellular and humoral immunity. This fact, coupled with the versatility and customizability of proteins when considering vaccine design a...
A new study from Emory University found that 23% of parents of children between ages 19 and 35 months old have skipped at least one vaccine and 14% do not follow guidelines
Lab Chip, 2020, Accepted Manuscript DOI: 10.1039/C9LC01165J, PaperJose Wippold, Han Wang, Joseph Tingling, Julian Leibowitz, Paul de Figueiredo, Arum Han Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for those infectious agents. However, current approaches for identifying neutralizing Abs (nAbs)... The content of this RSS Feed (c) The Royal Society of Chemistry
The quadrivalent version of Fluad was safe and effective against influenza strains included in the vaccine in multiple clinical studies with adults aged 65 years or older.News Alerts
Participants involved in a survey conducted by Onduo found continuous glucose monitors (CGM) to be highly effective. The results were presented at the 13th International Conference on Advanced Technologies &Treatments for Diabetes held in Madrid, Spain last week. The satisfaction survey was completed by 594 members who wore a CGM from March 2018 through July 2019.An overwhelming majority of survey participants (95% or greater) reported that the use of CGM helped increase their diabetes knowledge, including the impact of eating and taking medications. Survey respondents also reported being highly satisfied with the ease...