T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells.
T-bet and Gata3 in controlling type 1 and type 2 immunity mediated by innate lymphoid cells. Curr Opin Immunol. 2013 Apr;25(2):139-47 Authors: Hoyler T, Connor CA, Kiss EA, Diefenbach A Abstract Innate lymphoid cells (ILCs) are an emerging group of innate lymphocytes that share functional and transcriptional attributes with the various T helper cell effector fates (e.g. Th1, Th2, Th17). ILCs are substantially represented in the intestinal mucosa but are rare in secondary lymphoid organs. They play important roles in epithelial homeostasis, tissue repair and in immunity to intestinal infections. They are also involved in immune-mediated pathology. Here, we will review the emerging roles of the transcription factors T-bet and Gata3 in the development, lineage specification and function of distinct ILC lineages. We will also highlight the requirement of these transcriptional programs for the control of infections and the pathogenesis of inflammatory diseases. PMID: 23490163 [PubMed - in process]
To compare pre- and postoperative MRI-based anatomical findings following native tissue prolapse repair.
To compare changes in body image among women with uterovaginal prolapse undergoing vaginal mesh hysteropexy (mesh hysteropexy) or vaginal hysterectomy with uterosacral ligament suspension (hysterectomy).
Our objective was to evaluate the utility of concomitant injection of a human plasma derived exosome product (Purified Exosome Product; PEP) during surgical repair of anal sphincter injuries in a porcine model of obstetric anal sphincter injury. We aimed to evaluate the impact on anorectal manometry parameters and wound healing.
To compare the incidence of perioperative adverse events in women undergoing vaginal prolapse repair with uterine preservation (hysteropexy) versus concurrent hysterectomy.
Women consider preservation and improvement of sexual function (SF) an important goal following pelvic organ prolapse (POP) surgery. We aimed to systematically review and compare sexual activity and function before and after prolapse surgery in native tissue (NT) repairs, transvaginal synthetic mesh (TVM), biologic grafts (BG), and sacrocolpopexy (SCP).
To test the hypothesis that preoperative levator ani muscle (LAM) and transvaginal pudendal nerve (PN) injections with bupivacaine and dexamethasone would improve postoperative pain after vaginal apical prolapse repair.
In Sub-Saharan Africa, obstetric fistulas are a health crisis of extensive proportions. Successful closure is possible in the majority of cases though failures do occur. Although risk factors for failure are described, little exists regarding differences in risk factors for early and late recurrences. Our objective was to identify early and late failures and to identify risk factors for each.
Prior studies demonstrated that genital hiatus (GH) decreases following surgical correction of the vaginal apex. We hypothesized that the underlying levator hiatus (LH) and levator area (LA) would decrease following apical suspension in women with preoperative prolapse (POP) beyond the hymen. Our objective was to compare LH and LA on transvaginal 3D ultrasound (US) and the GH, as measured by POP-Q exam, before surgery and at 14 weeks following sacrocolpopexy without posterior repair or perineorrhaphy.
In this study, our primary objective was to determine the incidence of and risk factors for perioperative blood transfusions after urogenital fistulae repair in Uganda.
To evaluate the cost effectiveness of three routes of surgical repair for apical prolapse.