Manipulating the PD-1 pathway to improve immunity.

Manipulating the PD-1 pathway to improve immunity.
Curr Opin Immunol. 2013 Apr 9;
Authors: Kamphorst AO, Ahmed R
Abstract
PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and cancer. Nonetheless, combining PD-1 pathway blockade to therapeutic vaccination should further improve T cell rescue. PD-1 is induced shortly after T cell priming, but little is known about the role of PD-1 in the initiation of immune responses. In addition, the PD-1 pathway may also modulate humoral responses, since both B cells and Tfh cells express PD-1. Therefore, even though much progress has been achieved by manipulation of the PD-1 pathway to rescue exhausted T cells, this powerful immunotherapy could still be further exploited.
PMID: 23582509 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - April 9, 2013 Category: Allergy & Immunology Authors: Kamphorst AO, Ahmed R Tags: Curr Opin Immunol Source Type: research