Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging

Pulmonary edema is a cardinal feature of heart failure but no quantitative tests are available in clinical practice. The goals of this study were to develop a simple cardiovascular magnetic resonance (CMR) app...
Source: Journal of Cardiovascular Magnetic Resonance - Category: Radiology Authors: Tags: Research Source Type: research

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Left ventricular noncompaction cardiomyopathy is a heart disease with relevant potential complications including heart failure, life-threatening arrhythmias, and embolic events. In order to prevent adverse outcomes, it is crucial to appropriately recognize and manage this cardiomyopathy. In this paper, we report the main clinical presentations and imaging modalities used for diagnosis, including echocardiography and magnetic resonance imaging. We highlight the role of a comprehensive functional cardiac evaluation and the possible prognostic implications of both systolic and diastolic dysfunction. Furthermore, we summarize ...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
In a healthy subject, the left ventricle (LV) generates pressure by twisting, whereas the right ventricle (RV) dose so mainly by longitudinal shortening. Right ventricular (RV) function is recognized as a prognostic predictor in patients with left-sided heart failure. However, previous studies have focused on the global RV function such as RV ejection fraction (RVEF), not on RV morphological change.Cardiac magnetic resonance imaging (CMR) is a powerful imaging modality to assess RV morphological change which enables quantitative analysis of RV longitudinal and transverse shortening together with its global function.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (360) Source Type: research
Dilated cardiomyopathy (DCM) is a common cause of advanced heart failure (HF) in children and the risk of sudden death in DCM is not well defined although population-based studies have described risk factors like older age, familial DCM and lower fractional shortening. Myocardial fibrosis as assessed by late gadolinium enhancement (LGE) on 3-T cardiac magnetic resonance imaging (CMR) is well known to be associated with adverse events in DCM. We sought to assess the conditional survival (CS) of children and adolescents with DCM and advanced HF based on native T1 mapping (combined proton signal from myocytes and interstitium...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (301) Source Type: research
In conclusion, our experimental findings indicate that the epicardial microstructure is more vulnerable to high blood pressure leading to more pronounced changes in this region during remodeling. DT-MRI is well-suited for elucidating these alterations. The revealed transmural nonuniformity of myocardial reorganization may shed light on the mechanisms of the microstructure-function relationship in hypertension progression. Our results provide insights into the management of patients with systemic arterial hypertension, thus prevent the progression toward heart failure. The findings of this study should be acknowledged by el...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
r M Abstract Treatment of heart failure with preserved ejection fraction (HFpEF) remains a major unmet medical need. An implantable valveless pulsatile pump with a single cannula-the CoPulse pump-may provide beneficial hemodynamic support for select HFpEF patients when connected to the failing ventricle. We aimed to demonstrate hemodynamic efficacy and hemocompatible design feasibility for this novel assist device. The hemodynamic effect of the pump was investigated with an in vitro circulatory mock loop and an ex vivo isolated porcine heart model. The hydraulic design was optimized using computational fluid ...
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Ann Biomed Eng Source Type: research
We present a young man with signs and symptoms of heart failure and reduced left ventricular function in echocardiography who showed distinctive left ventricle features of saw tooth cardiomyopathy (saw tooth appearance of myocardium in basal inferolateral and basal to mid lateral segments) in cardiac magnetic resonance imaging.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
This study was designed as a multicenter, double-blind, randomized, placebo-controlled, parallel-group, superiority trial. Participants were randomly assigned in a 1:1 ratio through a centrally controlled, computer-generated, simple randomization schedule. The primary outcome was left ventricular end-diastolic volume index  = left ventricular end-diastolic volume/body surface area. The combined secondary outcomes include traditional Chinese medicine syndrome score, echocardiogram results, 6-minute walk test results, Seattle Angina Questionnaire score, cardiac magnetic resonance imaging results, biological ind...
Source: Trials - Category: Research Source Type: clinical trials
AbstractDirect stenting (DS) without pre-dilatation of the culprit lesion might improve myocardial perfusion and prognosis in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI); however, some studies report conflicting results. We investigated whether DS provides incremental myocardial benefits over conventional stenting (CS) in STEMI patients based on cardiac magnetic resonance imaging (CMR) measures. Reperfused patients who underwent CMR examinations within 1  week of STEMI onset were selected from a multicenter CMR registry of STEMI (NCT: 03768453). Patients were s...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractHypertrophic cardiomyopathy (HCM) is a genetic cardiomyopathy with a wide spectrum of clinical manifestations. Patients can be asymptomatic or suffer major adverse events including sudden cardiac death, ventricular arrhythmias, and heart failure. Identification of individuals with HCM who are at risk for these complications remains challenging. While echocardiography remains the mainstay of diagnostic evaluation, cardiac magnetic resonance imaging (CMR) is an important adjunctive diagnostic modality with emerging applications for risk-stratification of adverse events in the HCM population. Although not included in ...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
AbstractAn elderly patient with head injury was registered to the emergency room. Because the patient arrived to the hospital unconscious, her cranial, cerebrovascular, and cardiac function was studied. The cardiac function measurements were (i) heart rate, (ii) blood pressure, (iii) oxygen saturation level, (iv) electrocardiogram (ECG), (v) coronary angiogram, (vi) chest computerized tomography (CT), and (vii) echocardiogram. The head damage was studied by cerebral CT and magnetic resonance imaging (MRI). The serum ischemia and inflammatory biomarkers were analysed. For the immediate treatment, the patient received cardio...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
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