The Prevalence of Viral infections in children with cystic fibrosis (CF) in a tertiary care center in Saudi Arabia

ConclusionViral infections contributed to the increase in morbidity and mortality of CF patients in our population, and rhinovirus was the most common causative agent. Viral infections and viral recurrence increased the prevalence of bacterial infection of specific pathogens such as H. influenza and S. aureus. Physicians should be aware to prevent progressive lung damage in CF patients by treating the concomitant viral and bacterial infections. Viral infection may be associated with some common CFTR mutations.
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research

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Publication date: Available online 16 October 2019Source: Materials Science and Engineering: CAuthor(s): Rodianah Alias, Reza Mahmoodian, Krishnamurithy Genasan, Vellasamy K.M., Mohd Hamdi Abd Shukor, Tunku KamarulAbstractSurgical site infection associated with surgical instruments has always been a factor in delaying post-operative recovery of patients. The evolution in surface modification of surgical instruments can be a potential choice to overcome the nosocomial infection mainly caused by bacterial populations such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. A study was, therefore, conducte...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 19 October 2019Source: Food ChemistryAuthor(s): Tiantian Min, Zhu Zhu, Xiaoli Sun, Zhipeng Yuan, Junwei Zha, Yongqiang WenAbstractIn this work, a multifunctional food packaging composite coating with transparent, biodegradable, antifogging and antibacterial properties was designed and fabricated by quaternary ammonium salt modified chitosan (HACC) and poly (vinyl alcohol) (PVA) via a facile and environment-friendly solution casting method. A simple quaternization modification enabled the coating simultaneously to achieve excellent antifogging and antibacterial functions. The excellent ant...
Source: Food Chemistry - Category: Food Science Source Type: research
In this study, we discovered potent p53-MDM2 inhibition by 2-thiobenzyl-3-formyl quinoline, 2-thio-1,2-dihydroquinoline-3-formyl N-substituted thiosemi-carbazone and fluorine substituted new pyridine and pyran derivatives by structure-based design.Graphical abstract
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Mahmoud Amouzadeh Tabrizi, Josep Ferré-Borrull, Lluis F. MarsalAbstractFoodborne Salmonella disease is a major public health concern. Therefore, it is crucial to design a reliable biosensor to the diagnosis of this disease. Herein, we fabricated an interferometric reflectance spectroscopy (IRS) based DNA sensor for the determination of Salmonella-specific DNA fragment concentration. For this purpose, the nanoporous anodic alumina (NAA) was first fabricated. The pore walls of NAA were then functionalized with 3-amino...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 19 October 2019Source: Inorganica Chimica ActaAuthor(s): Ayman K. El-Sawaf, El Hassane AnouarAbstractThe (E)-N'-(2-hydroxybenzylidene)morpholine-4-carbothiohydrazide (H2L) ligand and its chelates with Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) have been synthesized. Analytical and spectral data prove that the ligand acts a monobasic tridentate ligand coordinated via deprotonated phenolic O, azomethine N and thione S atoms (ONS chromophore) with cobalt(II), nickel(II) and copper(II) salts leading to two fused five and six-membered chelate rings. While with zinc(II) and cadmium(II) salts the...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Authors: Paterson SL, Barry PJ, Horsley AR Abstract Introduction: Cystic fibrosis (CF) is a complex, multi-system, genetic disease affecting over 70,000 people worldwide. The underlying defect is a mutation in the CFTR gene. Dysfunctional CFTR protein results in abnormal anion movement across epithelial membranes in affected organs. There has been a paradigm shift in CF treatment over the last decade with the advent of CFTR modulation, treatments which target this underlying genetic defect and have the potential to change the course of CF clinical disease. Areas covered: Available CFTR modulators in current clinica...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Conclusions: The camel festival risk assessment highlights the need for an all-hazard approach to mass gatherings risk assessment. There is a need for multi-sectorial collaboration to strengthen the existing capacity, including disease surveillance. PMID: 31625590 [PubMed - in process]
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
Jennifer M. Rudd1, Sivasami Pulavendran1, Harshini K. Ashar1, Jerry W. Ritchey1, Timothy A. Snider1, Jerry R. Malayer1, Montelongo Marie1, Vincent T. K. Chow2 and Teluguakula Narasaraju1* 1Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, United States2Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore Exaggerated host innate immune responses have been implicated in severe influenza pneumonia. We have previously demonstrated that excessive neutrophils recruited during in...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: S. aureus, P. aeruginosa, coagulase negative staphylococci, and H. influenzae dominated in the upper airways of patients with CF. In patients with PCD, H. influenzae, S. pneumoniae, and P. aeruginosa dominated. When studies that included swab and blowing samples were excluded, P. aeruginosa was the most common bacterium in both groups. Direct comparisons among the studies were restricted due to very heterogeneous methods, and a better standardization of procedures and outcomes is needed. PMID: 28859703 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
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