Membranoproliferative glomerulonephritis following tubulointerstitial nephritis is a late manifestation of IgG4-related kidney disease: A distinctive case

Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Joichi Usui, Steven P. Salvatore, Mourhege Alsaloum, Alla Goldberg, Sheng Kuo, Surya V. SeshanAbstractIgG4-related kidney disease (IgG4RKD) generally presents as an active and chronic fibrosing tubulointerstitial nephritis. Recent reports have described glomerular lesions, typically with IgG4 containing subepithelial/membranous deposits as part of IgG4RKD. Herein, we report a case of IgG4-related membranoproliferative glomerulonephritis and associated tubulointerstitial nephritis in the clinical setting of IgG4-related autoimmune disease. A 75-year-old male diabetic patient with renal dysfunction showed IgG4-related tubulointersitital nephritis (TIN) superimposed on mild diabetic nephropathy by renal biopsy and was on 2 months of steroid therapy. Three years later, he developed progressive renal failure and heavy proteinuria leading to a second biopsy which showed, IgG4-dominant membranoproliferative pattern of glomerulonephritis (MPGN) along with chronic fibrosing IgG4-related tubulointerstitial disease. The development of MPGN is a rare lesion in association with IgG4 related TIN and may represent a late manifestation of IgG4RKD or continued complement activation.
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research

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