Down-regulation of ERMN expression in relapsing remitting multiple sclerosis

AbstractMultiple Sclerosis (MS) is a chronic inflammatory disease causing demyelination and neurodegeneration in the central nervous system (CNS). Although the exact etiology of MS is still unclear, both genetic and environmental elements are regarded as causative factors. Environmental factors can induce a cascade of events in immune system leading to neuronal death and nerve demyelination. This paper aims to compare the peripheral transcript levels ofErmin (ERMN) (a gene with putative role in cytoskeletal rearrangements during myelinogenesis) andListerin E3 Ubiquitin Protein Ligase 1 (LTN1) (a gene with functions in regulating innate immune system) between relapsing-remitting MS (RR-MS) patients and healthy controls. The results showed a significant decrease inERMN expression (p = 0.022); whereas, no significant difference was detected inLTN1 expression between two groups (p = 0.935). The reduction inERMN expression in leukocytes could be the cause of demyelinating process in RR-MS patients. Current findings might also have practical importance in prognosis and targeted therapies.
Source: Metabolic Brain Disease - Category: Neurology Source Type: research

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Publication date: Available online 18 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Jeannette Lechner-Scott, Emmanuelle Waubant, Michael Levy, Christopher Hawkes
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 16 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Edgar Carnero C, Pablo A. López, Juan Pablo Pettinicchi, Ricardo Alonso, Santiago Tizio, Verónica Tkachuk, Alejandro Caride, Ian GaleaAbstractBackgroundDemographics, clinical and imaging prognostic factors have been reported in large series of people with multiple sclerosis (PwMS). However, personalized long-term prognosis (LTP) is varied and uncertain in each particular case. Currently, there is limited evidence on how PwMS feel about prognosis communication and their coping strategies. Therefore, we ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionDMF influences the balance between proinflammatory and regulatory T cells, presumably favoring a less proinflammatory environment. DMF also reduces the CNS migratory potential of CD4+ T cells whereas CD8+ T cells are less affected. Altogether, our study suggests an anti-inflammatory effect of DMF mainly on the CD4+ T cell compartment.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 12 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Shahin Khayambashi, Amber Salter, Tuula Tyry, Gary R. Cutter, Robert J. Fox, Ruth Ann MarrieAbstractObjectiveWe aimed to determine the association between gender identity and sexual orientation on health care utilization in persons with multiple sclerosis (MS), as well as satisfaction with their doctor and comfort discussing sexual health with their doctor.MethodsWe surveyed participants from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding their gender identity and sexual ori...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Condition:   Multiple Sclerosis Intervention:   Procedure: perturbation training Sponsor:   Suleyman Demirel University Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis Intervention:   Other: data record Sponsors:   University Hospital, Toulouse;   French Association for Research on Multiple Sclerosis Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Relapsing Multiple Sclerosis (RMS) Intervention:   Biological: Ublituximab Sponsor:   TG Therapeutics, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
TIME held its first TIME 100 Health Summit on Thursday aiming to define — and shape — the future of health care. The Summit, which is an offshoot of the magazine’s annual TIME 100 list of influential people, featured scientists, politicians and entertainers, such as former President Bill Clinton, former Vice President Al Gore, NIH Director Dr. Francis Collins, actress Selma Blair, NBA commissioner Adam Silver, comedian Tig Notaro and former Planned Parenthood President Dr. Leana Wen. The day included a range of interviews, panels and performances. Here are the biggest moments from the Summit. Former Vice ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Comedy HealthSummit19 onetime Source Type: news
Leukocyte trafficking is a key event during autoimmune and inflammatory responses. The subarachnoid space (SAS) and cerebrospinal fluid are major routes for the migration of encephalitogenic T cells into the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, and are sites of T cell activation before the invasion of CNS parenchyma. In particular, autoreactive Th1 and Th17 cell trafficking and reactivation in the CNS are required for the pathogenesis of EAE. However, the molecular mechanisms controlling T cell dynamics during EAE are unclear. We used t...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Objective: To investigate the imaging and biodistribution of a novel zirconium-89 (89Zr)-labeled mouse anti-cd20 monoclonal antibody (mAb) in control and experimental autoimmune encephalomyelitis (EAE) mice following subcutaneous (s. c.) and intravenous (i.v.) administration.Background: Anti-cd20-mediated B-cell depletion using mAbs is a promising therapy for multiple sclerosis. Recombinant human myelin oligodendrocyte glycoprotein (rhMOG)-induced EAE involves B-cell-mediated inflammation and demyelination in mice.Design/Methods: C57BL/6J mice (n = 39) were EAE-induced using rhMOG. On Day 14 post EAE induction, 89Zr-labele...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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