Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures

AbstractThe aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-oxidative stress (IM&NO) biomarkers as predictors of disability in multiple sclerosis (MS) patients. A total of 122 patients with MS were included; their disability was evaluated using the Expanded Disability Status Scale (EDSS) and IM&NO biomarkers were evaluated in peripheral blood samples. Patients with EDSS ≥3 were older and showed higher homocysteine, uric acid, advanced oxidized protein products (AOPP) and low-density lipoprotein (LDL)-cholesterol and higher rate of metabolic syndrome (MetS), while high-density lipoprotein (HDL)-cholesterol was lower than in patients with EDSS
Source: Metabolic Brain Disease - Category: Neurology Source Type: research

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This study paves the way to isotopomics of other steroids and similar molecular weight compounds. PMID: 31627808 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01647C, CommunicationLijun Zong, Yufeng Han, Lei Gao, Chao Du, Xiaopan Zhang, Lin Li, Xiao Huang, Jinhua Liu, Hai-Dong Yu, Wei Huang This communication describes a rational design of transparent paper-based biosensing platform for multi-target detection by wavelength-dependent absorbance/transmittance. The platform was successfully applied in examination of protein and cholesterol in serum... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsThe role of caregivers ’ age in their QoL differs depending on the nature of the stressor, and an accumulation of stressors can have a particularly negative impact on older caregivers. Interventions should be adapted for caregivers of different ages and take into account the particular sources of stress they have to cop e with.
Source: Quality of Life Research - Category: Health Management Source Type: research
This study aims to address this gap.MethodsThe study used data from the Nihon University Japanese Longitudinal Study of Aging (NUJLSOA) and incidence-based multistate life tables to estimate disabled and disability-free life expectancy based on the stroke status of Japanese residents aged 65 and older.ResultsJapanese stroke survivors aged 65 who experienced an initial disability-free state could expect to live approximately 3 fewer total years of life, 4 –5 fewer years in a disability-free state, and 1–2 more years in a disabled state compared to those without history of a stroke (p 
Source: Quality of Life Research - Category: Health Management Source Type: research
Shaggy aorta is defined by diffuse, ulcerated plaques arising in the descending thoracic aorta and often extending through the abdominal and visceral segment. Two types of emboli originating from atherosclerotic plaques can be distinguished: thromboemboli and atheroemboli (cholesterol crystal emboli). These plaques may lead to visceral, pelvic, or peripheral embolization syndromes and have been shown to be associated with a higher 30- day mortality after endovascular aneurysm repair (EVAR) and open aortic repair (OAR).
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The objective of this study was to report on long-term survival of major lower limb amputees after rehabilitation as well as to identify factors leading to poorer survival.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
This study evaluated whether the expression and cellular localization of periostin changes in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis. Western blot analysis revealed that periostin was significantly upregulated in the spinal cord of EAE-induced mice in the effector stage, and did not significantly decrease in the recovery stage of EAE, compared with normal control. Periostin was constitutively detected in the neurons, ependymal cells, vascular endothelial cells, and astrocytes of normal mice. In the paralytic stage of EAE, periostin immunorea...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
(Natural News) Multiple sclerosis is scary enough on its own, especially since it is expensive and painful to treat. But a new study warns that one out of every five patients diagnosed with the disease has a different medical condition that shares the same symptoms. A common cause of disability, multiple sclerosis takes place when...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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