A single nucleotide polymorphism within Ninjurin 2 is associated with risk of multiple sclerosis

AbstractMultiple sclerosis (MS) is a devastating inflammatory disease of the central nervous system (CNS) associated with loss of myelin sheaths. The role of Schwan cells in the remyelination of MS lesions has been documented. However, the detailed steps of this process are unknown.Ninjurin 2 (NINJ2) encodes an adhesion protein with high expression in Schwann cells adjoining the distal piece of injured nerve. Based on the role of this protein in neurite outgrowth, it might participate in the process of nerve regeneration after nerve damage. In the present study, we genotyped twoNINJ2 single nucleotide polymorphisms (SNPs) namely rs11833579 and rs3809263 in a population of Iranian patients with MS as well as healthy individuals. The frequency of T allele of the rs3809263 was significantly higher in MS patients compared with healthy subjects (OR (95% CI)  = 1.33 (1.08–1.63), adjustedP value  = 0.01). TT genotype of this SNP was associated with MS risk compared with CC genotype (OR (95% CI) = 2.22 (1.37–3.57), adjustedP value  = 0.009). Moreover, the rs3809263 was associated with MS risk in recessive model (OR (95% CI) = 2.09 (1.33–3.31), adjusted P value = 0.003). There were no significant difference in the alleles and genotypes frequencies of rs11833579 between cases and controls. The current research sug gests contribution ofNINJ2 in the pathogenesis of MS and warrants furthe...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research

Related Links:

In this study, we analyzed the phenotypic feature of peripheral blood mononuclear cells (PBMCs) in MS patients and found that the patients exhibited an increase in the frequency of B cells, but a markedly decrease in frequency of CD5+ and IL-10+ B cells compared to healthy controls. Infusion of MSCs exhibited a significant therapeutic effect on the experimental autoimmune encephalomyelitis (EAE) mice, infiltration of mononuclear cells and demyelination of the spinal cords were both reduced in CNS of the mice, the frequency of CD5+ IL-10+ B cells in the mice was significantly increased. Additionally, when PBMCs or B cells f...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Conclusions: The reduced mobility may prevent pwMS participating in society. However, few studies investigating interventions or rehabilitation options to improve mobility were found in the existing literature, highlighting an until now under recognised unmet need.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 21 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Anna M. Pietroboni, Francesca Schiano di Cola, Annalisa Colombi, Tiziana Carandini, Chiara Fenoglio, Laura Ghezzi, Milena A. De Riz, Fabio Triulzi, Elio Scarpini, Alessandro Padovani, Daniela GalimbertiAbstractBackgroundNeurodegeneration is present from the earliest stages of multiple sclerosis (MS) and is critically involved in MS related clinical disability. Aim of the present study was to assess the connection between amyloid burden and early cerebellar grey matter (GM) atrophy compared to early brain GM atrophy ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Authors: Gay F Abstract Intranasal administration delivers molecules directly to the brain bypassing the blood-brain barrier. Three distinct routes of access have been identified; olfactory, trigeminal and via the paranasal sub-mucosa of the posterior sinuses. Consequently, environmental toxins may access the CNS directly to induce inflammatory and degenerative disease. They may also activate bacterial species of the nasal mucosal microbiome to release both immune-deviating cell wall antigens and transportable neurotoxins with local direct access to the CNS. Evidence is reviewed that toxins of the nasal bacterial m...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewOlder adults currently represent the fastest growing demographic of cannabis users, yet few studies have investigated the effects of cannabis use on cognitive functioning in aging. We conducted a systematic review of the recent literature examining cognitive outcomes associated with cannabis use in older adults, with and without neurocognitive disorders, to clarify the potential neuroprotective benefits or risks of cognitive decline in this population.Recent FindingsWe identified 26 studies examining cognitive outcomes associated with medical and recreational use of cannabis in healthy aging, demen...
Source: Current Addiction Reports - Category: Addiction Source Type: research
Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy homeostasis, drug addiction, and cognitive processes. These effects are mediated by two G protein-coupled receptor (GPCR) subtypes named OX1R and OX2R. In accordance with the synergic and dynamic relationship between the nervous and immune systems, orexins also have neuroprotective and immuno-regulatory (i.e., anti-inflammatory) properties. The present review gathers recen...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Olga Boukrina, Ekaterina Dobryakova, Veronica Schneider, John DeLuca, Nancy ChiaravallotiAbstractThe modified Story Memory Technique (mSMT) is a memory rehabilitation program that combines training in visualization and context formation to improve learning and memory. Previous studies have shown improvement in learning and memory in individuals with multiple sclerosis (MS) after undergoing the mSMT, including changes in brain activity related to working memory and word encoding. The current study examined changes i...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Source: Journal of Neurology - Category: Neurology Source Type: research
More News: Brain | Iran Health | Multiple Sclerosis | Neurology | Study