Protective Effects of TRPV1 Activation Against Cardiac Ischemia/Reperfusion Injury Is Blunted by Diet-Induced Obesity.

Protective Effects of TRPV1 Activation Against Cardiac Ischemia/Reperfusion Injury Is Blunted by Diet-Induced Obesity. Cardiovasc Hematol Disord Drug Targets. 2019 Sep 12;: Authors: Zhong B, Ma S, Wang DH Abstract BACKGROUND: Activation of transient receptor potential vanilloid subtype 1 (TRPV1) channels protects the heart from ischemia/reperfusion (I/R) injury through releasing calcitonin gene-related peptide (CGRP) and substance P (SP). The current study aimed to study the cardioprotective effects of TRPV1 in obesity. METHODS: TRPV1 gene knockout (TRPV1-/-) and wild-type (WT) mice were fed a high-fat diet (HFD) or a control diet or for 20 weeks, and then the hearts were collected for I/R injury ex vivo. The hearts were mounted on a Langendorff apparatus and subjected to ischemia (30 min) and reperfusion (40 min) after incubated with capsaicin (10 nmol/L), CGRP (0.1 µmol/L), and SP (0.1 µmol/L). Then, coronary flow, left ventricular peak positive dP/dt (+dP/dt), left ventricular developed pressure (LVDP), and left ventricular end-diastolic pressure (LVEDP) were measured. RESULTS: HFD intake remarkably reduced CF, +dP/dt, and LVDP and elevated LVEDP in both strains (P
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

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