Prevalence and Intensity of Smoking in Older Patients with Coronary Heart Disease Living in the Extreme North

AbstractThis paper analyzes the prevalence and intensity of smoking and its correlation with other risk factors of coronary artery disease among patients with chronic coronary artery disease aged 60 years and over living in the extreme North on the basis of ethnicity, age, and gender. A dependence of smoking on age is observed in non-indigenous patients. Smoking is less prevalent among women compared to men and among long-livers in comparison with the elderly and senile age. High intensity and long history of smoking are revealed in both ethnic groups of male patients. The average smoking history of smokers at the time of the survey is more than 50 years, and that of former smokers more than 30 years. High smoking index (SI) of more than 25 pack-years is observed in both ethnic groups. SI of more than 25 pack-years is 1.5 times more common in non-indigenous patients compared to the group of Yakuts. The highest SI is observed in the group of patients under 75 years. The higher the smoking index in non-indigenous smoking patients, the lower their HDL cholesterol levels regardless of the place of birth and the length of stay in the extreme North. The analysis reveals the correlation of smoking with other risk factors: blood lipids, arterial pressure (AP), body mass index (BMI), and abdominal obesity (AO), as well as the dependence of myocardial infarction on the smoking history and the smoking index value. Smoking cessation leads to lower blood pressure and BMI and promotes high...
Source: Advances in Gerontology - Category: Geriatrics Source Type: research

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HEART ATTACKS are often caused by coronary heart disease, and risk of developing this is increased by a high-fat diet, high cholesterol and being overweight or obese. Research in the past has found a link between eating certain foods and heart disease, but a new study has confirmed a popular breakfast food is not as bad as first though.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Hongfei Gu1†, Shuang Shao2†, Jie Liu3,4,5, Zhenqian Fan2, Yu Chen2, Jingxian Ni3,4,5, Conglin Wang6, Jun Tu3,4,5, Xianjia Ning3,4,5, Yongzhong Lou1*, Bin Li1* and Jinghua Wang3,4,5* 1Department of Neurology, Tianjin Haibin People's Hospital, Tianjin, China 2Department of Endocrinology and Metabolism, The Second Hospital of Tianjin Medical University, Tianjin, China 3Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China 4Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China 5Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study also identified the cardiac myocyte as a significant local source of BDNF, as cardiac myocyte-specific deletion of BDNF induced a similar cardiomyopathy phenotype. While these results do not exclude a role for other neurotrophins, particularly in injury states, they point to the requirement for continued, local synthesis of BDNF to maintain optimal cardiac function. A major, unresolved question relates to how the truncated TrkB isoform (TrkBT1) transduces the inotropic effects of BDNF, which will require additional study. A concurrent study evaluated the potential impact of the BDNF-mediated activation of the k...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In conclusion, FGF21 belongs to a promising class of cytokines that are induced in response to stress and that can be used as a drug, drug target, or through a biomarker, depending on the physio-pathological context. All these findings will become clear when FGF21 will be used as a therapeutic molecule, exploiting the beneficial effects of FGF21 for treating metabolic disease or when it will be blocked to ameliorate disease progression and the onset of disease. Author Contributions CT and MS wrote the manuscript. VR contributed to the discussion. Funding This work was supported from the AFM-Telethon (19524), Italian Mi...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: The lipidome is altered in ART-treated HIV infection, and may contribute to inflammation and CVD progression. Detailed lipidomic analyses may better assess CVD risk in both HIV+ and HIV– individuals than does traditional lipid profiling. Introduction Both HIV infection and the use of antiretroviral therapy (ART) contribute to an increased risk for cardiovascular disease (CVD) (1, 2). Dyslipidemia is observed in HIV-infected (HIV+) individuals, and is associated with reduced levels of high-density lipoprotein (HDL) cholesterol, and elevated total (TC) cholesterol, low-density lipoprotein (LDL) chole...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions Aging leads to a progressive decrease in androgen production that, in turn, leads to the development of LOH, defined by significant low T serum levels (in the lowest quartile) in the presence of signs and symptoms of hypogonadism (51). LOH could be due to both testicular and hypothalamic-pituitary dysfunction (32), and ED is one of its main symptoms. ED in LOH is linked to increased oxidative stress, subclinical inflammation, and subsequent endothelial dysfunction (101). In elderly men, it has been shown that LOH is also linked to lower cAMP pool and to an alteration of the cGMP signaling pathway. PDE5 gene l...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Shafqat Ahmad1,2,3*, Syeda Sadia Fatima4, Gull Rukh5 and Caren E. Smith6 1Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden 2Preventive Medicine Division, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States 3Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, United States 4Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan 5Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden 6Nutrition and Genomics Laboratory, Jean Mayer U. S. Depa...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Liu W, Wang T, Sun P, Zhou Y Abstract Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
No one ever had fun visiting the cardiologist. ­Regardless of how good the doc might be, it’s always a little scary thinking about the health of something as fundamental as the heart. But there are ways to take greater control—to ensure that your own heart health is the best it can be—even if you have a family history of cardiovascular disease. Although 50% of cardiovascular-disease risk is genetic, the other 50% can be modified by how you live your life, according to Dr. Eugenia Gianos, director of Women’s Heart Health at Lenox Hill Hospital in New York City. “This means you can greatly ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Baby Boomer Health heart health Source Type: news
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