[Risedronate inhibits rat bone marrow adipogenesis and reduces RANKL expression in adipocytes].
CONCLUSIONS: Risdronate can effectively inhibit the adipogenic differentiation of rat BMSCs, decrease fat content in the bone marrow, and suppress the generation and function of osteoclasts by down-regulating the expression of RANKL, which can be an important mechanism underlying the therapeutic effect of risedronate against osteoporosis.
PMID: 31511221 [PubMed - in process]
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Jin J, Jin D Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
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