CHA2DS2-VASc Score for Identifying Patients at high risk of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-analysis

ConclusionsThe CHA2DS2-VASc score has relatively good performance in predicting POAF after cardiac surgery and may help identify the patients at high risk of POAF.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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Authors: Cox JL, McCarthy PM PMID: 31632786 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Publication date: Available online 22 October 2019Source: Indian Heart JournalAuthor(s): Sunny Goel, Shanti Patel, Elina Zakin, Ravi Teja Pasam, Joseph Gotesman, Bilal Ahmad Malik, Sergey Ayzenberg, Robert Frankel, Jacob ShaniAbstractObjectivesTo compare safety and efficacy of Patent Foramen Ovale (PFO) closure compared with medical therapy in patients with cryptogenic stroke (CS)BackgroundThe role of PFO closure in preventing recurrent stroke in patients with prior CS has been controversial.MethodsWe searched PubMed, EMBASE, the Cochrane Central Register of Controlled trials, and the clinical trial registry maintained at ...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Condition:   Atrial Fibrillation Intervention:   Procedure: radiofrequency ablation Sponsor:   Henan Institute of Cardiovascular Epidemiology Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study it was found that cardiac glycosides selectively eliminate many types of senescent cells, including when senescence has been triggered by irradiation, cancer itself, or chemotherapeutic drugs - such as etoposide or doxorubicin. The fact that ouabain can eliminate different types of senescent cells emphasises its potential as a broad spectrum senolytic. "These drugs are already used in the clinic, so they could be repurposed to treat a long list of diseases including cancer. This is something we are keen to explore with our clinical collaborators. Moreover, many patients are being treated with digo...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Heart failure (HF) has been associated with an increased incidence of thromboembolic events, while many HF deaths have been thought to be of thrombotic aetiology.1 In terms of pathophysiology, HF bears several prothrombotic features. The deceleration of peripheral and intracardiac blood flow due to peripheral congestion and impaired cardiac contractility, respectively, the prolonged bed rest in severely ill cases, the associated endothelial dysfunction, the increased risk for atrial fibrillation (AF) due to structural and electrical atrial remodelling in the presence of elevated atrial pressures due to left ventricular dys...
Source: Cardiovascular Research - Category: Cardiology Source Type: research
In conclusion, electrical and structural remodeling arising from the PITX2c p.Met207Val mutation may increase atrial susceptibility to arrhythmia due to shortened APD, reduced CV and increased tissue vulnerability, which, in combination, facilitate initiation and maintenance of re-entrant excitation waves.
Source: Frontiers in Physiology - Category: Physiology Source Type: research
A 68-year old man with a history of hypertension, diabetes, coronary artery disease and an obliterating lower limbs arteritis, presented for a stroke. Electrocardiogram did not show atrial fibrillation nor ischemic electrocardiographic signs. White blood cell count (10800/m3) was high but eosinophil count (234/mm3) was normal. Atherosclerosis origin of the stroke was suspected.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Medical Imagery Source Type: research
Postoperative atrial fibrillation (POAF) after cardiac surgery remains a highly prevalent and costly condition that negatively impacts patient quality of life and survival. Numerous retrospective studies, meta-analysis, and review papers have been reported identifying POAF risk based on patients ’ risk factors and clinical biomarkers. In this narrative review, the authors report significant variations among selected pre- and perioperative biomarkers used to predict POAF incidence in patients without a history of atrial fibrillation (AF).
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Review Article Source Type: research
ConclusionA considerable burden of previously unknown AF was detected when long-term monitoring was applied in at-risk patients. Biomarkers were associated with AF incidence and improved prediction of long AF episodes.
Source: American Heart Journal - Category: Cardiology Source Type: research
ConclusionsOur results suggest that sex-specific differences in LV geometry, hyper-contractility and diastolic function, not greater degree of LV myopathy, contribute to a higher, age-independent risk of diastolic HF in women with HCM.Graphical abstract
Source: American Heart Journal - Category: Cardiology Source Type: research
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