Significant Improvements in Mortality after the Fontan Operation in Children with Down Syndrome

The objective was to show the contemporary short-term outcome of the Fontan operation for a functionally univentricular heart in patients with DS and non-DS, along with an analysis of significant predictors for in-hospital mortality.MethodsThis was a retrospective study using the Society of Thoracic Surgeons Congenital Database to assess in-hospital mortality and its predictors in patients with DS and non-DS undergoing the Fontan operation over 16 years (2001-2016). The primary outcome was in-hospital mortality. Statistical analysis was performed using univariable and multivariable logistic regression models.ResultsOur study cohort consisted of 12,074 patients (81 DS and 11,993 non-DS). The overall in-hospital mortality rate significantly improved in the recent era (2009 – 2016): 2.4% to 1.3%, p
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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Source: Clinical and Experimental Gastroenterology - Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research
Conditions:   Down Syndrome;   Obstructive Sleep Apnea Interventions:   Behavioral: Family-informed intervention;   Behavioral: Standard Clinical Care Sponsors:   Children's Hospital of Philadelphia;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   Children's Hospital Medical Center, Cincinnati;   University of Pennsylvania Not yet recruiting
Source: - Category: Research Source Type: clinical trials
This study is the first to report the presence of defective interhemispheric connectivity at the time of birth in Ts65Dn mice, providing evidence that early therapeutic intervention may be an effective time window for the treatment of Down syndrome.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
ConclusionCardiac myxomas are the most frequent finding among primary cardiac tumors. Clinical manifestations depend on the involvement in valvular obstruction, distant arterial embolisms, or nonspecific, constitutional symptoms. Transoesophageal Echocardiography is the cornerstone for diagnosis of atrial myxoma. Cardiac myxomas should be managed with surgical resection.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Contributor : Keiichi IshiharaSeries Type : Expression profiling by arrayOrganism : Mus musculusThe Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16, of which a large portion is homologous to human chromosome 21. The mouse model shows an impaired neurogenesis at E14.5. We analyzed the effect of Ts1Cje trisomic region on global gene expression in the embryonic brain of Ts1Cje mice at E14.5.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
A divided federal appeals court on Friday said Ohio cannot enforce a 2017 law banning abortions when medical tests show that a fetus has Down syndrome.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Upchurch A, Sharma S, Hadigal S, Wagner M, Berry R. Persistent hypoxemia in a teen with down syndrome.J Clin Sleep Med. 2019;15(10):1547–1549.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
AbstractThe aim of this research study was to examine the effects of Assisted Cycling Therapy (ACT) on adaptive/maladaptive behaviors, depression, and self-efficacy in adolescents with Down syndrome (DS). The participants were counterbalanced to either intervention groups of 1) Assisted Cycling Therapy (ACT), in which the participants ’ voluntary pedaling rates were augmented with a motor to ensure the maintenance of 80 rpm or greater 2) Voluntary Cycling (VC), in which participants cycled at their self-selected pedaling rate or 3) No Cycling (NC), in which the participants sat and watched a video. The ACT and V...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
Abstract Toilet training is a significant developmental milestone in early childhood. Most U.S. children achieve the physiologic, cognitive, and emotional development necessary for toilet training by 18 to 30 months of age. Markers of readiness for toilet training include being able to walk, put on and remove clothing, and follow parental instruction; expressive language; awareness of a full bladder or rectum; and demonstrated dissatisfaction with a soiled diaper. Other readiness cues include imitating toileting behavior, expressing desire to toilet, and demonstrating bladder or bowel control (staying dry through ...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
ConclusionOur patients in this cohort demonstrated the well ‐established benefits of robotic sternal‐sparing cardiac surgery, including excellent intra and postoperative outcomes and accelerated recovery.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
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