User stories as lightweight requirements for agile clinical decision support development

ConclusionsUser stories concisely communicate thewho,what, andwhy of a CDS request, and serve as lightweight requirements for agile development to meet the demand for increasingly diverse CDS.
Source: Journal of the American Medical Informatics Association - Category: Information Technology Source Type: research

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WEDNESDAY, Nov. 20, 2019 -- There are associations between rheumatoid arthritis (RA) and multiple comorbidities before and after diagnosis, with inflammatory bowel disease, type 1 diabetes, and venous thromboembolism (VTE) occurring more often...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionIntegrated data show that baricitinib is well ‐tolerated in EA patients with moderate‐to‐severely active RA in the context of demonstrated efficacy, which is generally consistent with safety results of the overall study population.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
We present 2 cases in which the diagnosis of pulmonary thromboembolism was made in patients whose only known risk factor was RA. PMID: 31676697 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
A new boxed warning has been added to the labeling of tofacitinib (Xeljanz, Xeljanz XR) based on preliminary safety data from an ongoing postmarketing trial showing an increased risk of thrombosis and death in patients with at least one cardiovascular risk factor who were taking the 10-mg twice-daily dose.Tofacitinib 10 mg twice daily is approved as induction treatment for ulcerative colitis; the dose is not approved to treat rheumatoid arthritis or psoriatic arthritis.NPs should adhere to the dosing regimens listed on tofacitinib's labeling. Patients should be assessed for thrombosis and taught to seek emergency help if t...
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
Background: Total hip arthroplasty (THA) relieves pain and restores function in patients with severe rheumatoid arthritis and osteoarthritis. Over the past few decades, several authors have attempted to assess the efficacy and safety of simultaneous bilateral THA compared with staged bilateral THA. The purpose of this meta-analysis is to compare the mortalities and complications between simultaneous bilateral THA and staged bilateral THA. Methods: A literature search to identify eligible studies was undertaken to identify all relevant articles published until August 2018. We included studies that compared simultaneous...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Date: August 26, 2019 Issue #:  1579Summary:  The FDA has required updates to the labeling of the Janus kinase (JAK) inhibitor tofacitinib(Xeljanz, Xeljanz XR) based on interim results of a postmarketing safety trial that showed an increased risk of pulmonary thromboembolism and death with a dosage of 10 mg twice daily.1 Tofacitinib is approved for treatment of rheumatoid arthritis (RA),2 psoriatic arthritis, and ulcerative colitis.In the postmarketing trial, RA patients ≥50 years old taking methotrexate who had at least one cardiovascular risk factor were randomized to receive add-on treatm...
Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Source Type: research
Abstract Accumulating observations in humans and animals indicate that inflammation plays a key role in atherosclerosis development and subsequent complications. Moreover, the use of loss- or gain-of-function genetically modified, atherosclerosis-prone mice has provided strong experimental evidence for a causal role of innate and adaptive immunity in atherosclerosis and has revealed the pathogenic activity of proinflammatory cytokines, including TNF (tumor necrosis factor)-α, IL (interleukin)-1β, IL-6, and IL-18, and the atheroprotective effect of anti-inflammatory cytokines, including IL-10 and TGF-&be...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
Authors: Vanni VS, De Lorenzo R, Privitera L, Canti V, Viganò P, Rovere-Querini P Abstract Introduction: Systemic Autoimmune Diseases (SADs) include systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, systemic sclerosis, Sjogren's syndrome, mixed connective tissue disease, idiopathic inflammatory myopathies and vasculitis. SADs often occur in women of childbearing age and can affect fertility. Both infertility treatments and fertility preservation techniques are thus often indicated. Areas covered: The literature regarding the safety of fertility-related drugs for both fer...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
CONCLUSION: Compared with csDMARDs and/or steroids without ABT, adding ABT to the treatment does not appear to increase the incidence rates of postoperative adverse events in RA patients undergoing orthopedic surgery. Large cohort studies should be performed to add evidence for the perioperative safety profile of ABT. PMID: 31203226 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
A 69-year-old man with a history of rheumatoid arthritis and pulmonary fibrosis presented with an incidentally discovered 11.5 cm left renal mass with a level 3 inferior vena cava (IVC) tumor thrombus, including involvement of the left adrenal and lumbar veins. The thrombus was highly vascularized as shown in Figure 1A-C. Preoperative evaluation was negative for metastatic disease and the serum creatinine (SCr) level was 1.55 mg/dL, correlating with an estimated glomerular filtration rate (eGFR) of 46 mL/min/1.73m2.
Source: Urology - Category: Urology & Nephrology Authors: Tags: Grand Rounds Source Type: research
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