Epstein-Barr virus latent membrane protein 1 (LMP1) regulates the aldehyde dehydrogenase (ALDH) positive cell population in nasopharyngeal carcinoma cell lines.

In this study, we overexpressed LMP1 in two NPC cell lines and found elevated level of cytokeratin 19 (CK19) expression. CK19 is an undifferentiated keratin and a stem cell marker. We also have found an increased number of ALDH positive cells along with LMP1 overexpression in both cell lines. Our data demonstrate that LMP1 regulates the maintenance of ALDH-1 positive NPC cancer stem cells, thus shedding light on target therapy of NPC in clinical application. Keywords: nasopharyngeal carcinoma; latent membrane protein 1; aldehyde dehydrogenase; cancer stem cells. PMID: 31507199 [PubMed - in process]
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research

Related Links:

Authors: Xu W, Lou Y, Chen W, Kang Y Abstract Effective cancer therapy usually requires the assistance of well-designed drug carriers. In order to increase the drug accumulation to tumor tissue as well as to reduce the side effects of drug carriers, the hybrid drug delivery system (DDS) was developed by integrating folic acid (FA) and a metal-organic framework (MOF). The anticancer drug doxorubicin (DOX) was preloaded into the MOF nanoparticles during the synthesis process of the MOF nanoparticles. After surface modification with FA, the resulting FA/MOF/DOX nanoparticles were capable of serving as a biocompatible ...
Source: Biomedizinische Technik/Biomedical Engineering - Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research
What are the latest strategies for fertility preservation in adolescent and young adult survivors of childhood cancer?Current Opinion in Urology
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Urology Journal Article Source Type: news
The aim of this study is to evaluate the association between metabolic disorders and the risk of nasopharyngeal carcinoma, considering different histological subtypes. Between 1992 and 2008, we carried out a multicentre case–control study in Italy. One-hundred and ninety-seven White patients with histologically confirmed nasopharyngeal carcinoma were enrolled as cases. The control group included 592 cancer-free patients, frequency matched by study centre, area of residence, sex, age and period of interview. Odds ratios (OR) and corresponding 95% confidence intervals (CI), for nasopharyngeal carcinoma according to obe...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Head and Neck Cancer Source Type: research
Authors: Roy Chattopadhyay N, Das P, Chatterjee K, Choudhuri T Abstract Nasopharyngeal carcinoma (NPC) is a rare variety of head and neck cancers. The risk factors include three major causes: genetic factors, viral infection, and environmental and dietary factors. The types of NPC show strong ethnic and geographic variations. The keratinizing and non-keratinizing types are prevalent in the lower incidence regions like North America and Europe; whereas the undifferentiated type is mostly found in the regions with higher incidences like China, North Africa, Arctic, and Nagaland of North-East India. These suggest a po...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
CONCLUSION: Patients treated with cetuximab had more cutaneous toxicities, but oral toxicity was similar between groups. The different IMRT modalities did not induce different toxicity profiles. PMID: 27345843 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
Conclusion EBV radiosensitized the p53 mutant tobacco associated head and neck cell line, FaDu. Objectives In the head and neck, HPV is a major risk factor associated with tonsil and base of tongue cancers, while a majority of undifferentiated nasopharyngeal cancers are positive for EBV. Clinically, head and neck tumors positive for HPV or EBV are more radiosensitive than tumors associated with tobacco and alcohol. This study aimed to evaluate whether viral infections can sensitize tobacco-associated head and neck squamous cell carcinoma cell line that harbors multiple mutations, especially TP53, to radiotherapy. Method Fo...
Source: Acta Oto-Laryngologica - Category: ENT & OMF Authors: Tags: Acta Otolaryngol Source Type: research
Lymphoepithelial carcinoma (LEC) is one of 24 subtypes of salivary gland cancers, a group of rare malignancies that together only represent 5% of head and neck cancers [1,2]. Salivary LEC is exquisitely rare and comprises only 0.4% of salivary cancers [3]. It shares similar histopathological features as non-keratinizing, undifferentiated nasopharyngeal carcinomas (NPC), but are found at other sites, most commonly in the parotid gland [4]. Knowledge of the subject is limited to case reports and small case series, most of which report female patients of Arctic Inuit (Eskimo), Southern Chinese, or Greenlandic descent with str...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
This article will review current literature on the association of HPV with Scheiderian papillomas, sinonasal squamous cell carcinoma, sinonasal undifferentiated carcinoma, carcinoma with adenoid cystic-like features and nasopharyngeal carcinoma.
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research
Nasopharyngeal carcinoma (NPC), with a remarkably distinctive ethnic and geographic distribution, has the highest incidence among Southern Chinese. Unlike other types of head and neck cancers, a unique feature of NPC is its close association with Epstein-Barr virus (EBV). EBV infection represents an early event during the pathogenesis of NPC. Latent EBV infection is found in every cancer cell of virtually all cases of undifferentiated NPC in endemic regions. Genetic alterations in the premalignant epithelium may support the EBV latency. Although EBV-encoded proteins in its latent infection, including LMP1, LMP2A, etc., hav...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Carcinogenesis Source Type: research
Most commonly head and neck squamous cell carcinoma (HNSCC) are located in the oral cavity, oropharynx, hypopharynx or larynx. Nasopharyngeal carcinoma (NPC) is considered as a separate tumour because of pathology (squamous cell carcinoma or undifferentiated carcinoma), treatment and prognosis. Worldwide the estimated number of HNSCC cases was 599,000 and of NPC 87,000 in 2012, which together comprised 4.8% of all cancer incidences making HNSCC and NPC the seventh most frequent cancer site. Worldwide the estimated number of cancer deaths from HNSCC was 325,000 and from NPC 51,000in 2012, which accounted for 4.6% of all cancer deaths [1].
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | China Health | Genetics | Head and Neck Cancer | Infectious Diseases | Nasopharyngeal Cancer | Stem Cell Therapy | Stem Cells | Study | Undifferentiated Carcinoma | Virology