GSTO1 regards as a meritorious regulator in cutaneous malignant melanoma cells

ConclusionsTo sum up, our outcomes exhibited that weakening GSTO1 reduced the proliferation and mobility of CMM cells, increased the apoptosis ability of CMM cells, and arrested cell cycle at G1 phase, which can be achieved by affecting the expression of PCNA, p53 and the EMT process. This discovery provided a new perspective for elucidating the mechanism of CMM, and offered theoretical support for searching clinical therapeutic targets in the future.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research