A multi-method and structure-based in silico vaccine designing against Echinococcus granulosus through investigating enolase protein.

Conclusion: Based on the results, this step-by-step immunoinformatics approach could be considered as a rational platform for designing vaccines against such multi-stage parasites. Furthermore, it is proposed that this multi-epitope vaccine is served as a promising preventive anti-echinococcosis agent. PMID: 31508329 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research

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Publication date: Available online 19 October 2019Source: Materials Science and Engineering: CAuthor(s): Camilo A.S. Ballesteros, Daniel S. Correa, Valtencir ZucolottoAbstractSmart nanomaterials activated by light is one of the most exciting strategies to control the release of substances in varied environments. Here we developed a smart nanomaterial formed by a photoresponsive nanogel containing silver nanoparticles (AgNPs) immobilized on the surface of biodegradable polycaprolactone (PCL) nanofibers mats produced by electrospinning. The silver nanoparticles (AgNps) are released from the nanogel and dispersed inside the n...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, for developing a scaffold for tissue engineering from fish processing wastes, a hierachial collagen/gelatin/chitosan novel porous scaffold was fabricated using blends of collagen and gelatin extracted from the skins of Marine big eye snapper Priacanthus humrur. Scaffolds were developed by mechanical spinning of chitosan and by mixing of collagen and gelatin solutions followed by freeze drying and subsequent crosslinking of polymers. The scaffolds were evaluated for rheological properties – porosity, apparent density and swelling capacity to assess their mechanical property.Gelatin/chitosan composition ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 19 October 2019Source: Food ChemistryAuthor(s): Tiantian Min, Zhu Zhu, Xiaoli Sun, Zhipeng Yuan, Junwei Zha, Yongqiang WenAbstractIn this work, a multifunctional food packaging composite coating with transparent, biodegradable, antifogging and antibacterial properties was designed and fabricated by quaternary ammonium salt modified chitosan (HACC) and poly (vinyl alcohol) (PVA) via a facile and environment-friendly solution casting method. A simple quaternization modification enabled the coating simultaneously to achieve excellent antifogging and antibacterial functions. The excellent ant...
Source: Food Chemistry - Category: Food Science Source Type: research
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Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
The objective of this study was to evaluate post-vaccine antibody titers and circulating cellular memory development in heifers fed OG and administered a commercially available modified-live bovine respiratory disease (BRD) vaccine. Twenty-four Holstein heifers were assigned to one of two diets for 170 days: Control TMR (CON; n = 11), or TMR plus OG (TRT; 9 g/100 kg BW/day; n = 13). Samples for hematology, serology, and cellular assays were collected on D-110, 0, 21, 42, and 60 of the trial. Heifers were administered two priming doses of a modified-live BRD vaccine, with a third dose given on D0. There were n...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
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Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
[The Conversation Africa] The theme for World Health Day in 1995 was "Target 2000 -- A World Without Polio". I delivered a lecture titled "Polio Eradication Race: Will Nigeria Finish Last?" to mark the occasion. Finishing last seemed likely because in the 1990s Nigeria's routine immunisation rates were in the 30%-40% range for all vaccine preventable diseases. Countries in Southern and East Africa that had eradicated polio had coverage in the 80%-90% range.
Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
Publication date: Available online 19 October 2019Source: Journal of BiotechnologyAuthor(s): Julia Tröndle, Kristin Schoppel, Arne Bleidt, Natalia Trachtmann, Georg A. Sprenger, Dirk Weuster-BotzAbstractE. coli strain NT1259 /pF112aroFBLkan was able to produce 14.3 g L-1 L-tryptophan within 68 h in a fed-batch process from glycerol on a 15 L scale. To gain detailed insight into metabolism of this E. coli strain in the fed-batch process, a sample of L-tryptophan producing cells was withdrawn after 47 h, was separated rapidly and then resuspended in four parallel stirred-tank bioreactors with...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
Authors: Tianli L, Xifeng W, Zhenzhong T, Lixia W, Xingxing Z, Jun Q, Qingling M, Shasha G, Ying C, Xuepeng C Abstract Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) and...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
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