The role of G protein-coupled estrogen receptor 1 on neurological disorders.

The role of G protein-coupled estrogen receptor 1 on neurological disorders. Front Neuroendocrinol. 2019 Sep 09;:100786 Authors: Roque C, Mendes-Oliveira J, Duarte-Chendo C, Baltazar G Abstract G protein-coupled estrogen receptor 1 (GPER) is a membrane-associated estrogen receptor (ER) associated with rapid estrogen-mediated effects. Over recent years GPER emerged has a potential therapeutic target to induce neuroprotection, avoiding the side effects elicited by the activation of classical ERs. The putative neuroprotection triggered by GPER selective activation was demonstrated in mood disorders, Alzheimer's disease or ParkinsoĊ„s disease of male and female in vivo rodent models. In others, like ischemic stroke, the results are contradictory and currently there is no consensus on the role played by this receptor. However, it seems clear that sex is a biological variable that may impact the results. The major objective of this review is to provide an overview about the physiological effects of GPER in the brain and its putative contribution in neurodegenerative disorders, discussing the data about the signaling pathways involved, as well as, the diverse effects observed. PMID: 31513775 [PubMed - as supplied by publisher]
Source: Frontiers in Neuroendocrinology - Category: Endocrinology Authors: Tags: Front Neuroendocrinol Source Type: research